Abstract
Glycyrrhizic acid (GA) is a triterpenoid saponin glycoside from licorice roots and rhizomes, having a variety of pharmacological activities, but its solubility in water is poor. In this study, we got GA nanoparticle suspensions about 180 nm by SAS (supercritical antisolvent) process. Comparative anti HSV-1 (herpes simplex virus type 1) studies were undertaken using nano-GA (glycyrrhizic acid nanoparticles) with its ammoniated salt--- MAG (glycyrrhizic acid ammonium salt). The maximum noncytotoxic concentration of both nano-GA and MAG were 187.5 μM for BHK cells. MTT assay showed GA nanoparticle suspensions exhibited better anti-HSV activities compared to MAG, especially during replication period. Morphology of HSV-1 observed by TEM (transmission electron microscopy) significantly changed with nano-GA treatment. TEM images showed that the envelope of HSV-1 was damaged and shedded.
Keywords: Glycyrrhizic acid, herpes simplex virus type 1, nanoparticle, supercritical antisolvent process.
Current Nanoscience
Title:Anti-HSV-1 Activity of Glycyrrhizic Acid Nanoparticles Prepared by Supercritical Antisolvent Process
Volume: 11 Issue: 3
Author(s): Wei Wang, Yan-li Zhao, Xiu-hua Zhao, Yuan-gang Zu and Yu-jie Fu
Affiliation:
Keywords: Glycyrrhizic acid, herpes simplex virus type 1, nanoparticle, supercritical antisolvent process.
Abstract: Glycyrrhizic acid (GA) is a triterpenoid saponin glycoside from licorice roots and rhizomes, having a variety of pharmacological activities, but its solubility in water is poor. In this study, we got GA nanoparticle suspensions about 180 nm by SAS (supercritical antisolvent) process. Comparative anti HSV-1 (herpes simplex virus type 1) studies were undertaken using nano-GA (glycyrrhizic acid nanoparticles) with its ammoniated salt--- MAG (glycyrrhizic acid ammonium salt). The maximum noncytotoxic concentration of both nano-GA and MAG were 187.5 μM for BHK cells. MTT assay showed GA nanoparticle suspensions exhibited better anti-HSV activities compared to MAG, especially during replication period. Morphology of HSV-1 observed by TEM (transmission electron microscopy) significantly changed with nano-GA treatment. TEM images showed that the envelope of HSV-1 was damaged and shedded.
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Cite this article as:
Wang Wei, Zhao Yan-li, Zhao Xiu-hua, Zu Yuan-gang and Fu Yu-jie, Anti-HSV-1 Activity of Glycyrrhizic Acid Nanoparticles Prepared by Supercritical Antisolvent Process, Current Nanoscience 2015; 11 (3) . https://dx.doi.org/10.2174/1573413711666150123230335
DOI https://dx.doi.org/10.2174/1573413711666150123230335 |
Print ISSN 1573-4137 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6786 |
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