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Current Organic Chemistry


ISSN (Print): 1385-2728
ISSN (Online): 1875-5348

Some Recent Synthetic Development on Compounds with Potent Activities on Hormone-sensitive Breast Cancers

Author(s): Zheng Wang, Hui-Lei Gao and Xu-Dong Chen

Volume 19 , Issue 10 , 2015

Page: [898 - 918] Pages: 21

DOI: 10.2174/1385272819666150123000346

Price: $65


Hormone-sensitive breast cancers correspond to breast tumors with the existence of estrogen and progesterone in the tumor issue. The hormones estrogen and progesterone may in some circumstance promote the growth of breast cancers. Therefore, compounds targeting hormone-sensitive breast cancers have attracted considerable interest from synthetic organic chemists. In the past two decades, numerous compounds have thus been designed and synthesized to investigate their anti-breast cancer activities. In this review, some recent synthetic endeavor in the past five years towards compounds targeting hormone-sensitive breast cancers, especially estrogenreceptor positive breast cancers, are summarized.

Keywords: Anti-breast cancer, Estrogen-receptor, ER-positive, hormone-sensitive, MCF-7, stereo-control, synthesis, total synthesis.

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