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Current Genomics


ISSN (Print): 1389-2029
ISSN (Online): 1875-5488

Heart Failure in Chronic Myocarditis: A Role for microRNAs?

Author(s): P. van den Hoogen, F. van den Akker, J.C. Deddens and J.P.G. Sluijter

Volume 16, Issue 2, 2015

Page: [88 - 94] Pages: 7

DOI: 10.2174/1389202916999150120153344

Price: $65


Myocarditis is an inflammatory disease of the heart, which can persist over a long time. During this time, known as the chronic phase of myocarditis, ongoing inflammation damages the cardiomyocytes. The loss of cardiac cells culminates in the development of dilated cardiomyopathy, often followed by non-ischemic heart failure due to diminished cardiac function. During the course of the disease, expression levels of non-coding small RNAs, called microRNAs (miRNAs), change. Although mainly studied in the acute setting, some of these changes in expression level appear to persist in the chronic phase. In addition to being a much-needed diagnostic tool, these miRNA could provide new treatment options. miRNA-based intervention strategies already showed promising results in the treatment of ischemic cardiovascular diseases in preclinical animal models. By implementing more knowledge on the role of miRNAs in the progression towards heart failure, this can potentially be used in the development of miRNA-based therapeutic interventions in the treatment of myocarditis and thereby preventing the progression towards heart failure. The first part of this review will focus on the natural course of myocarditis and the progression towards heart failure. Secondly, we will discuss the current knowledge on alterations of miRNA expression patterns, and suggest some possible future interventions.

Keywords: Dilated cardiomyopathy, Heart failure, Inflammation, miRNA, Myocarditis, Therapy.

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