Abstract
Heart failure (HF) is a common disease with high morbidity and mortality; however, none of the drugs available are now entirely optimal for the treatment of HF. In addition to various clinical diseases and environment influences, genetic factors also contribute to the development and progression of HF. Identifying the common variants for HF by genome-wide association studies will facilitate the understanding of pathophysiological mechanisms underlying HF. This review summarizes the recently identified common variants for HF risk and outcome and discusses their implications for the clinic therapy.
Keywords: Common variants, Dilated cardiomyopathy, Genome-wide association studies, Heart failure, Mortality, Risk.
Current Genomics
Title:Common Variants for Heart Failure
Volume: 16 Issue: 2
Author(s): Shutong Shen, Lichan Tao, Xiuzhi Wang, Xiangqing Kong and Xinli Li
Affiliation:
Keywords: Common variants, Dilated cardiomyopathy, Genome-wide association studies, Heart failure, Mortality, Risk.
Abstract: Heart failure (HF) is a common disease with high morbidity and mortality; however, none of the drugs available are now entirely optimal for the treatment of HF. In addition to various clinical diseases and environment influences, genetic factors also contribute to the development and progression of HF. Identifying the common variants for HF by genome-wide association studies will facilitate the understanding of pathophysiological mechanisms underlying HF. This review summarizes the recently identified common variants for HF risk and outcome and discusses their implications for the clinic therapy.
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Cite this article as:
Shen Shutong, Tao Lichan, Wang Xiuzhi, Kong Xiangqing and Li Xinli, Common Variants for Heart Failure, Current Genomics 2015; 16 (2) . https://dx.doi.org/10.2174/1389202916999150120153141
DOI https://dx.doi.org/10.2174/1389202916999150120153141 |
Print ISSN 1389-2029 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5488 |
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