Abstract
Individual microRNAs and/or microRNA signatures were associated with Alzheimer’s disease (AD). We report here the recent advances brought to the identification of microRNA changes in AD brain and their biological function in the molecular pathways associated with the disease. This field represents a fertile route to understand the pathogenic mechanisms underlying Alzheimer’s disease. In addition we review recent studies aimed to discover promising biomarkers for AD diagnosis by microRNA expression profiles of biofluids from AD patients.
Keywords: Alzheimer’s disease, APP, microRNAs, tau.
CNS & Neurological Disorders - Drug Targets
Title:MicroRNA Landscape in Alzheimer’s Disease
Volume: 14 Issue: 2
Author(s): Carlo Cogoni, Francesca Ruberti and Christian Barbato
Affiliation:
Keywords: Alzheimer’s disease, APP, microRNAs, tau.
Abstract: Individual microRNAs and/or microRNA signatures were associated with Alzheimer’s disease (AD). We report here the recent advances brought to the identification of microRNA changes in AD brain and their biological function in the molecular pathways associated with the disease. This field represents a fertile route to understand the pathogenic mechanisms underlying Alzheimer’s disease. In addition we review recent studies aimed to discover promising biomarkers for AD diagnosis by microRNA expression profiles of biofluids from AD patients.
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Cite this article as:
Cogoni Carlo, Ruberti Francesca and Barbato Christian, MicroRNA Landscape in Alzheimer’s Disease, CNS & Neurological Disorders - Drug Targets 2015; 14 (2) . https://dx.doi.org/10.2174/1871527314666150116123305
DOI https://dx.doi.org/10.2174/1871527314666150116123305 |
Print ISSN 1871-5273 |
Publisher Name Bentham Science Publisher |
Online ISSN 1996-3181 |
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