Abstract
The progress in both peptide and polymer chemistry has led to the preparation of “hybrids” to yield compounds with properties not achievable with the separate components. In this review we aim at describing the current synthetic methodologies for the preparation of peptide containing block copolymers, either being completely peptidic or as hybrids with synthetic polymer blocks. The different techniques to prepare these polymers are ordered by level of control over peptide sequence and hence their molecular structure. First, recent developments in NCA polymerization will be discussed, which enable the construction of well-defined high molecular weight peptide based block copolymers, albeit with no absolute control over amino acid composition. Solution phase peptide synthesis allows the preparation of small peptide sequences, which can be incorporated into the side chain or the main chain of hybrid polymer architectures. Application of solid phase peptide synthesis and the newly developed peptide ligation methods has resulted in an extension of the length of the peptide fragments that can be conveniently incorporated into hybrid polymer structures. Finally absolute control over amino acid sequence, combined with the ability to create high molecular weight species is accomplished with the application of protein engineering to the field of polymer science.
Keywords: polymer chemistry, homopolypeptide, atom transfer radical polymerization (atrp), peptide transduction domain (ptd), chromatography, maldi-tof, epitopes
Current Organic Chemistry
Title: Peptide-Containing Block Copolymers: Synthesis and Potential Applications of Bio-Mimetic Materials
Volume: 9 Issue: 12
Author(s): J. M. Smeenk, D. W.P.M. Lowik and J. C.M. van Hest
Affiliation:
Keywords: polymer chemistry, homopolypeptide, atom transfer radical polymerization (atrp), peptide transduction domain (ptd), chromatography, maldi-tof, epitopes
Abstract: The progress in both peptide and polymer chemistry has led to the preparation of “hybrids” to yield compounds with properties not achievable with the separate components. In this review we aim at describing the current synthetic methodologies for the preparation of peptide containing block copolymers, either being completely peptidic or as hybrids with synthetic polymer blocks. The different techniques to prepare these polymers are ordered by level of control over peptide sequence and hence their molecular structure. First, recent developments in NCA polymerization will be discussed, which enable the construction of well-defined high molecular weight peptide based block copolymers, albeit with no absolute control over amino acid composition. Solution phase peptide synthesis allows the preparation of small peptide sequences, which can be incorporated into the side chain or the main chain of hybrid polymer architectures. Application of solid phase peptide synthesis and the newly developed peptide ligation methods has resulted in an extension of the length of the peptide fragments that can be conveniently incorporated into hybrid polymer structures. Finally absolute control over amino acid sequence, combined with the ability to create high molecular weight species is accomplished with the application of protein engineering to the field of polymer science.
Export Options
About this article
Cite this article as:
Smeenk M. J., Lowik W.P.M. D. and van Hest C.M. J., Peptide-Containing Block Copolymers: Synthesis and Potential Applications of Bio-Mimetic Materials, Current Organic Chemistry 2005; 9 (12) . https://dx.doi.org/10.2174/1385272054553622
DOI https://dx.doi.org/10.2174/1385272054553622 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
Call for Papers in Thematic Issues
Advances of Heterocyclic Chemistry with Pesticide Activity
Global food safety and security will continue to be a global concern for the next 50 years and beyond. Plant diseases have had a significant impact on food safety and security throughout the entire food chain, from primary production to consumption. While conventional chemical pesticides have been traditionally used for ...read more
Calculation design of covalent/metal organic framework based catalysts
This research area combines theoretical computation and screening with machine learning for the design of covalent/metal organic framework-based catalysts, bridging the disciplines of organic chemistry, physical chemistry, computational chemistry, materials science, and machine learning. It covers several critical aspects: designing and synthesizing organic catalysts for improved performance, applying computational methods ...read more
Carbohydrates conversion in biofuels and bioproducts
Biomass pretreatment, hydrolysis, and saccharification of carbohydrates, and sugars bioconversion in biofuels and bioproducts within a biorefinery framework. Carbohydrates derived from woody biomass, agricultural wastes, algae, sewage sludge, or any other lignocellulosic feedstock are included in this issue. Simulation, techno-economic analysis, and life cycle analysis of a biorefinery process are ...read more
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Discovery of Medically Significant Lantibiotics
Current Drug Discovery Technologies Cardiovascular-Active Venom Toxins: An Overview
Current Medicinal Chemistry Identification of Molecular Targets Associated with Ethanol Toxicity and Implications in Drug Development
Current Pharmaceutical Design Synthesis and <i>In Silico</i> Studies of C-4 Substituted Coumarin Analogues as Anticancer Agents
Current Computer-Aided Drug Design Cellular Delivery In Vivo of siRNA-Based Therapeutics
Current Pharmaceutical Design Antagonism by Bioactive Polyphenols Against Inflammation: A Systematic View
Inflammation & Allergy - Drug Targets (Discontinued) Effects and Mechanisms of Medicinal Plants on Healing Scars: A Systematic Review
Current Traditional Medicine The Cancer Preventive Effects of Edible Mushrooms
Anti-Cancer Agents in Medicinal Chemistry TRPV4 Agonists and Antagonists
Current Topics in Medicinal Chemistry Drug-Induced Peripheral Neuropathy: Diagnosis and Management
Current Cancer Drug Targets A Rationale for Combined Therapy with a Calcium Channel Blocker and a Statin: Evaluation of Basic and Clinical Evidence
Current Drug Targets - Cardiovascular & Hematological Disorders Synthesis and Biological Screening of Lupeol-benzylidine Derivatives
The Natural Products Journal Update on Diagnostic and Treatment of Uncomplicated and Complicated Malaria in Adults and Selected Vulnerable Populations
Infectious Disorders - Drug Targets Hsp70s and J Proteins of Plasmodium Parasites Infecting Rodents and Primates: Structure, Function, Clinical Relevance, and Drug Targets
Current Pharmaceutical Design TNF-α Inhibition as a Treatment Strategy for Neurodegenerative Disorders: New Drug Candidates and Targets
Current Alzheimer Research Cell Sheet Technology for Heart Failure
Current Pharmaceutical Biotechnology Role of Polyphenol in Regulating Oxidative Stress, Inflammation, Fibrosis, and Apoptosis in Diabetic Nephropathy
Endocrine, Metabolic & Immune Disorders - Drug Targets The Paradox of Oestradiol-Induced Breast Cancer Cell Growth and Apoptosis
Current Signal Transduction Therapy Function and Chemotypes of Human Hsp70 Chaperones
Current Topics in Medicinal Chemistry Polyphenols and Stem Cells for Neuroregeneration in Parkinson’s Disease and Amyotrophic Lateral Sclerosis
Current Pharmaceutical Design