Abstract
Regenerative medicine holds much promise in assisting patients to recover from injured or lost tissues and organs through organism reconstruction. Three-dimensional (3D) biomimetic models via various approaches can be used by pharmaceutical industry for controlled drug delivery. With proper biomaterials and engineering technologies, drugs can be released in a rate-manipulated manner towards targeted regions with spatial and temporal effects. Much of the success is a result of a combination of growth factors, stem cells, biomaterials, nanotechnologies, electrospinning and 3D printing techniques mimicking in vivo angiogenesis, histogenesis and tumorigenesis processes. This interdisciplinary field on biomimetic drug delivery and regenerative medicine has already opened up a new avenue for medical progress and reformation. This article presents a comprehensive review of the 3D biomimetic models in the pertinent fields of tissue and organ manufacturing, cell-material mutual interactions, bioactive agent carrier systems and anti-cancer drug delivery methods. Particularly, the potential trends and challenges of tissue and organ manufacturing are discussed from different perspectives.
Keywords: Regenerative medicine, drug delivery, biomaterials, 3D models, nanotechnology.
Current Pharmaceutical Design
Title:Application of 3D Biomimetic Models in Drug Delivery and Regenerative Medicine
Volume: 21 Issue: 12
Author(s): Yufan Xu and Xiaohong Wang
Affiliation:
Keywords: Regenerative medicine, drug delivery, biomaterials, 3D models, nanotechnology.
Abstract: Regenerative medicine holds much promise in assisting patients to recover from injured or lost tissues and organs through organism reconstruction. Three-dimensional (3D) biomimetic models via various approaches can be used by pharmaceutical industry for controlled drug delivery. With proper biomaterials and engineering technologies, drugs can be released in a rate-manipulated manner towards targeted regions with spatial and temporal effects. Much of the success is a result of a combination of growth factors, stem cells, biomaterials, nanotechnologies, electrospinning and 3D printing techniques mimicking in vivo angiogenesis, histogenesis and tumorigenesis processes. This interdisciplinary field on biomimetic drug delivery and regenerative medicine has already opened up a new avenue for medical progress and reformation. This article presents a comprehensive review of the 3D biomimetic models in the pertinent fields of tissue and organ manufacturing, cell-material mutual interactions, bioactive agent carrier systems and anti-cancer drug delivery methods. Particularly, the potential trends and challenges of tissue and organ manufacturing are discussed from different perspectives.
Export Options
About this article
Cite this article as:
Xu Yufan and Wang Xiaohong, Application of 3D Biomimetic Models in Drug Delivery and Regenerative Medicine, Current Pharmaceutical Design 2015; 21 (12) . https://dx.doi.org/10.2174/1381612821666150115154059
DOI https://dx.doi.org/10.2174/1381612821666150115154059 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
Call for Papers in Thematic Issues
"Tuberculosis Prevention, Diagnosis and Drug Discovery"
The Nobel Prize-winning discoveries of Mycobacterium tuberculosis and streptomycin have enabled an appropriate diagnosis and an effective treatment of tuberculosis (TB). Since then, many newer diagnosis methods and drugs have been saving millions of lives. Despite advances in the past, TB is still a leading cause of infectious disease mortality ...read more
Current Pharmaceutical challenges in the treatment and diagnosis of neurological dysfunctions
Neurological dysfunctions (MND, ALS, MS, PD, AD, HD, ALS, Autism, OCD etc..) present significant challenges in both diagnosis and treatment, often necessitating innovative approaches and therapeutic interventions. This thematic issue aims to explore the current pharmaceutical landscape surrounding neurological disorders, shedding light on the challenges faced by researchers, clinicians, and ...read more
Emerging and re-emerging diseases
Faced with a possible endemic situation of COVID-19, the world has experienced two important phenomena, the emergence of new infectious diseases and/or the resurgence of previously eradicated infectious diseases. Furthermore, the geographic distribution of such diseases has also undergone changes. This context, in turn, may have a strong relationship with ...read more
Melanoma and Non-Melanoma Skin Cancer Treatment: Standard of Care and Recent Advances
In this thematic issue, we aim to provide a standard of care of the diagnosis and treatment of melanoma and non-melanoma skin cancer. The editor will invite authors from different countries who will write review articles of melanoma and non-melanoma skin cancers. The Diagnosis, Staging, Surgical Treatment, Non-Surgical Treatment all ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
The Prevalence of the Classical and Non-Classical Cardiovascular Risk Factors in Multiple Sclerosis Patients
CNS & Neurological Disorders - Drug Targets The Potent Inhibitory Effect of β-D-Mannuronic Acid (M2000) as a Novel NSAID with Immunosuppressive Property on Anti-Cyclic Citrullinated Peptide Antibodies, Rheumatoid Factor and Anti-dsDNA Antibodies in Patients with Rheumatoid Arthritis
Current Drug Discovery Technologies The Genetics of Small-Vessel Disease
Current Medicinal Chemistry Mechanisms of Corticosteroid Resistance in Severe Asthma and Chronic Obstructive Pulmonary Disease (COPD)
Current Pharmaceutical Design Lupus Nephritis: Current Treatment Paradigm and Unmet Needs
Reviews on Recent Clinical Trials Pediatric Immune Dysfunction and Health Risks Following Early-Life Immune Insult
Current Pediatric Reviews Cell Cycle Arrest as a Therapeutic Target of Acute Kidney Injury
Current Protein & Peptide Science Outcomes of Anticoagulant Therapy with Low-Molecular-Weight Heparin (LMWH) and Warfarin for Thromboangiitis Obliterans (TAO)
Current Vascular Pharmacology Top Three Pharmacogenomics and Personalized Medicine Applications at the Nexus of Renal Pathophysiology and Cardiovascular Medicine
Current Pharmacogenomics and Personalized Medicine Sexual Dimorphism in Autoimmune Disease
Current Molecular Medicine Glucagon Like Peptide-1 and Atherosclerosis
Cardiovascular & Hematological Agents in Medicinal Chemistry Multidrug Resistance Protein 4 (MRP4/ABCC4): A Suspected Efflux Transporter for Human’s Platelet Activation
Protein & Peptide Letters Acetylcholinesterase Inhibitors and Drugs Acting on Muscarinic Receptors- Potential Crosstalk of Cholinergic Mechanisms During Pharmacological Treatment
Current Neuropharmacology Novel Strategies in the Treatment of Pulmonary Arterial Hypertension
Current Drug Targets All in the Family: The TNF-TNFR Superfamily in the Pathogenesis and Treatment of Rheumatoid Arthritis and other Inflammatory Diseases
Current Medicinal Chemistry - Anti-Inflammatory & Anti-Allergy Agents Pleiotropic Effects of Statins in Atherosclerotic Disease: Focus on the Antioxidant Activity of Atorvastatin
Current Topics in Medicinal Chemistry Hendra and Nipah Viruses: Pathogenesis and Therapeutics
Current Molecular Medicine Long-Term Extensions of Randomized Vaccination Trials of ACC-001 and QS-21 in Mild to Moderate Alzheimer’s Disease
Current Alzheimer Research Excess Exposure to Insulin Is the Primary Cause of Insulin Resistance and its Associated Atherosclerosis
Current Molecular Pharmacology Transgenic Models in Allergic Responses
Current Drug Targets