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Cardiovascular & Hematological Disorders-Drug Targets


ISSN (Print): 1871-529X
ISSN (Online): 2212-4063

Sepsis Pathophysiology and Anesthetic Consideration

Author(s): Koichi Yuki and Naoka Murakami

Volume 15, Issue 1, 2015

Page: [57 - 69] Pages: 13

DOI: 10.2174/1871529X15666150108114810

Price: $65


Sepsis remains to be a significant health care issue associated with high mortality and healthcare cost, despite the extensive effort to better understand the pathophysiology of the sepsis. Recently updated clinical guideline for severe sepsis and septic shock, “Surviving Sepsis Campaign 2012”, emphasizes the importance of early goal-directed therapy, which can be implemented in intraoperative management of sepsis patients. Herein, we review the updates of current guideline and discuss its application to anesthesic management. Furthermore, we review the recent advance in knowledge of sepsis pathophysiology, focusing on immune modulation, which may lead to new clinical therapeutic approach to sepsis.

Keywords: Anesthetics, early goal-directed therapy, intraoperative, sepsis.

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