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Letters in Organic Chemistry


ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

Natural Organic Acids Promoted Synthesis of 3, 4-Dihydropyrimidin- 2(1H)-ones/thiones Under Solvent-free Conditions

Author(s): Nitin M. Thorat and Shankar R. Thopate

Volume 12, Issue 3, 2015

Page: [210 - 216] Pages: 7

DOI: 10.2174/1570178612666150108003629

Price: $65


Naturally occurring organic acids are reported to be highly efficient promoters for the Biginelli reaction under thermal and microwave irradiation using solvent free conditions. Among the various organic acids used, malic acid was found to be the most effective promoter for Biginelli reaction under above reaction conditions. Present protocol is a simple and eco-friendly route for the synthesis of 3, 4-dihydropyrimidin-2(1H)-ones/thiones.

Keywords: Biginelli reaction, 3, 4-dihydropyrimidin-2(1H)-ones/thiones, naturally occurring acid, green promoters, solventfree synthesis.

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