OPA1 in Cardiovascular Health and Disease

Title:OPA1 in Cardiovascular Health and Disease

Volume: 16 Issue: 8

Author(s): Niall Burke, Andrew R. Hall and Derek J. Hausenloy

Affiliation:

Keywords: Cardiovascular disease, fission, fusion, mitochondrial morphology, OPA1.

Abstract: Mitochondria are known to play crucial roles in normal cellular physiology and in more recent years they have been implicated in a wide range of pathologies. Central to both these roles is their ability to alter their shape interchangeably between two different morphologies: an elongated interconnected network and a fragmented discrete phenotype - processes which are under the regulation of the mitochondrial fusion and fission proteins, respectively. In this review article, we focus on the mitochondrial fusion protein optic atrophy protein 1 (OPA1) in cardiovascular health and disease and we explore its role as a potential therapeutic target for treating cardiovascular and metabolic disease.

Cite this article as:

Burke Niall, Hall R. Andrew and Hausenloy J. Derek, OPA1 in Cardiovascular Health and Disease, Current Drug Targets 2015; 16(8) . https://dx.doi.org/10.2174/1389450116666150102113648