OPA1 in Cardiovascular Health and Disease

Author(s): Niall Burke, Andrew R. Hall and Derek J. Hausenloy

Volume 16, Issue 8, 2015

Page: [912 - 920] Pages: 9

DOI: 10.2174/1389450116666150102113648

Price: $65

Abstract

Mitochondria are known to play crucial roles in normal cellular physiology and in more recent years they have been implicated in a wide range of pathologies. Central to both these roles is their ability to alter their shape interchangeably between two different morphologies: an elongated interconnected network and a fragmented discrete phenotype - processes which are under the regulation of the mitochondrial fusion and fission proteins, respectively. In this review article, we focus on the mitochondrial fusion protein optic atrophy protein 1 (OPA1) in cardiovascular health and disease and we explore its role as a potential therapeutic target for treating cardiovascular and metabolic disease.

Keywords: Cardiovascular disease, fission, fusion, mitochondrial morphology, OPA1.

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