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Current Protein & Peptide Science


ISSN (Print): 1389-2037
ISSN (Online): 1875-5550

Proline-Rich Peptides: Multifunctional Bioactive Molecules as New Potential Therapeutic Drugs

Author(s): Alberto Vitali

Volume 16, Issue 2, 2015

Page: [147 - 162] Pages: 16

DOI: 10.2174/1389203716666150102110817

Price: $65


Proline-rich peptides (PRPs) include a large and heterogeneous group of small-medium sized peptides characterized by the presence of proline residues often constituting peculiar sequences. This feature confers them a typical structure that determines the various biological functions endowed by these molecules. In particular the left-handed-polyproline-II helix is essential for the expression of the antimicrobial, immunomodulatory, antioxidant properties and to finely modulate protein-protein interactions, thus playing crucial roles in many cell signal transduction pathways. These peptides are widely diffuse in the animal kingdom and in humans, where they are present in many tissues and biological fluids. This review highlights the most relevant biological properties of these peptides, focusing on the potential therapeutic role that the PRPs may play as a promising source of new peptidebased novel drugs.

Keywords: Antimicrobial, drugs, polyproline-II helix, proline rich motifs, proline-rich peptides, protein-protein interactions.

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