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Current Topics in Medicinal Chemistry


ISSN (Print): 1568-0266
ISSN (Online): 1873-4294

Functionalization of Non-Activated C-H Bonds in the Synthesis of Vitamin D Metabolites and Analogs

Author(s): Edelmiro Moman

Volume 14, Issue 21, 2014

Page: [2398 - 2407] Pages: 10

DOI: 10.2174/1568026615666141208100811

Price: $65


The development of non-microbial methods for the selective functionalization of non-activated C-H bonds has constituted a challenge, with important economical and environmental implications, for chemists for over a century. The present review provides a comprehensive and current compendium that illustrates the power of C-H functionalization and, namely, of remote functionalization strategies, to expeditiously access vitamin D analogs with intricate structures.

Keywords: Analogs, calcitriol, Free radical, Non-activated carbons, Remote functionalization, Synthesis, Vitamin D.

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