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Current Topics in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1568-0266
ISSN (Online): 1873-4294

Gemini Analogs of Vitamin D

Author(s): Gonzalo Pazos, Marcos L. Rivadulla, Xenxo Perez-García, Zoila Gandara and Manuel Perez

Volume 14, Issue 21, 2014

Page: [2388 - 2397] Pages: 10

DOI: 10.2174/1568026615666141208100411

Price: $65

Abstract

The Gemini analogs are the last significant contribution to the family of vitamin D derivatives in medicine, for the treatment of cancer. The first Gemini analog was characterized by two symmetric side chains at C-20. Following numerous modifications, the most active analog bears a C-23-triple bond, C-26, 27- hexafluoro substituents on one side chain and a terminal trideuteromethylhydroxy group on the other side chain. This progression was possible due to improvements in the synthetic methods for the preparation of these derivatives, which allowed for increasing molecular complexity and complete diastereoselective control at C-20 and the substituted sidechains.

Keywords: Chemical synthesis, Gemini analogs, Steroid, Vitamin D.

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