Abstract
Influenza virus infections represent a big issue for public health since effective treatments are still lacking. In particular, the emergence of strains resistant to drugs limits the effectiveness of anti-influenza agents. For this reason, many efforts have been dedicated to the identification of new therapeutic strategies aimed at targeting the virus-host cell interactions. Oxidative stress is a characteristic of some viral infections including influenza. Because antioxidants defend cells from damage caused by reactive oxygen species induced by different stimuli including pathogens, they represent interesting molecules to fight infectious diseases. However, most of the available studies have found that these would-be panaceas could actually exacerbate the diseases they claim to prevent, and have thus revealed "the dark side" of these molecules. This review article discusses the latest opportunities and drawbacks of the antioxidants used in anti-influenza therapy and new perspectives.
Keywords: Anti-influenza therapy, Antioxidants, Antivirals, Influenza virus, Oxidative stress, Redox state.
Current Topics in Medicinal Chemistry
Title:Intracellular Redox State as Target for Anti-Influenza Therapy: Are Antioxidants Always Effective?
Volume: 14 Issue: 22
Author(s): Rossella Sgarbanti, Donatella Amatore, Ignacio Celestino, Maria Elena Marcocci, Alessandra Fraternale, Maria Rosa Ciriolo, Mauro Magnani, Raffaele Saladino, Enrico Garaci, Anna Teresa Palamara and Lucia Nencioni
Affiliation:
- Department of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy.,Italy
Keywords: Anti-influenza therapy, Antioxidants, Antivirals, Influenza virus, Oxidative stress, Redox state.
Abstract: Influenza virus infections represent a big issue for public health since effective treatments are still lacking. In particular, the emergence of strains resistant to drugs limits the effectiveness of anti-influenza agents. For this reason, many efforts have been dedicated to the identification of new therapeutic strategies aimed at targeting the virus-host cell interactions. Oxidative stress is a characteristic of some viral infections including influenza. Because antioxidants defend cells from damage caused by reactive oxygen species induced by different stimuli including pathogens, they represent interesting molecules to fight infectious diseases. However, most of the available studies have found that these would-be panaceas could actually exacerbate the diseases they claim to prevent, and have thus revealed "the dark side" of these molecules. This review article discusses the latest opportunities and drawbacks of the antioxidants used in anti-influenza therapy and new perspectives.
Export Options
About this article
Cite this article as:
Sgarbanti Rossella, Amatore Donatella, Celestino Ignacio, Marcocci Elena Maria, Fraternale Alessandra, Ciriolo Rosa Maria, Magnani Mauro, Saladino Raffaele, Garaci Enrico, Palamara Teresa Anna and Nencioni Lucia, Intracellular Redox State as Target for Anti-Influenza Therapy: Are Antioxidants Always Effective?, Current Topics in Medicinal Chemistry 2014; 14(22) . https://dx.doi.org/10.2174/1568026614666141203125211
DOI https://dx.doi.org/10.2174/1568026614666141203125211 |
Print ISSN 1568-0266 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4294 |

- Author Guidelines
- Editorial Policies
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Allegations from Whistleblowers
- Publishing Ethics and Rectitude
- Increase Visibility Of Your Article
- Archiving Policies
- Reviewer Guidelines
- Guest Editor Guidelines
- Board Recruitment Workflow
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Announcements
- Forthcoming Thematic Issues
Related Articles
-
Diabetes and Vascular Disease: Basic Concepts of Nitric Oxide Physiology, Endothelial Dysfunction, Oxidative Stress and Therapeutic Possibilities
Current Vascular Pharmacology Immunotherapeutic Approaches in Pancreatic Adenocarcinoma: Current Status and Future Perspectives
Current Molecular Pharmacology Drug-Related Cardiotoxicity for the Treatment of Haematological Malignancies in Elderly
Current Pharmaceutical Design Radioimmunotherapy of Solid Tumors: Searching for the Right Target
Current Drug Delivery A Review on Electrochemical Sensing of Cancer Biomarkers Based on Nanomaterial - Modified Systems
Current Analytical Chemistry Kinase Inhibitors in Multitargeted Cancer Therapy
Current Medicinal Chemistry Multiple Functions of Generic Drugs: Future Perspectives of Aureolic Acid Group of Anti-Cancer Antibiotics and Non-Steroidal Anti-Inflammatory Drugs
Mini-Reviews in Medicinal Chemistry Ionic Liquids, Microextraction Methods and Capillary Electrophoresis in Biomedical Research
Current Pharmaceutical Analysis Editorial [Hot Topic: New Therapies in Prostate Cancer: Controlling Metastatic Disease and Preventing Oncogenesis (Executive Editor: B.F. Schwartz )]
Current Pharmaceutical Design Advancing Metabolomics Research and Biomarker Application with Nanotechnology
Current Metabolomics Bevacizumab and Angiogenesis Inhibitors in the Treatment of CNS Metastases: The Road less Travelled
Current Molecular Pharmacology A Survey of Prostate Segmentation Techniques in Different Imaging Modalities
Current Medical Imaging Novel Genetic and Peptide-Based Strategies Targeting the Bcl-2 Family, an Update
Recent Patents on DNA & Gene Sequences Challenges and Successes Using Nanomedicines for Aerosol Delivery to the Airways
Current Gene Therapy Peptide Vaccines for Cancer Therapy
Recent Patents on Inflammation & Allergy Drug Discovery The Novel VEGF<sub>121</sub>-VEGF<sub>165</sub> Fusion Attenuates Angiogenesis and Drug Resistance via Targeting VEGFR2-HIF-1α-VEGF<sub>165</sub>/Lon Signaling Through PI3K-AKT-mTOR Pathway
Current Cancer Drug Targets Liposomes as Anticancer Therapeutic Drug Carrier’s Systems: More than a Tour de Force
Current Nanomedicine TRIM65 in White Matter Lesions, Innate Immunity, and Tumor
Current Molecular Pharmacology Cancer Drug Discovery Targeting Histone Methyltransferases: An Update
Current Medicinal Chemistry Trends and Topics in CD133 in Pubmed From 2000 to 2015
Current Biomarkers (Discontinued)