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Current Topics in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1568-0266
ISSN (Online): 1873-4294

Hydrophobic Plant Antioxidants. Preparation of Nanoparticles and their Application for Prevention of Neurodegenerative Diseases. Review and Experimental Data

Author(s): Vladimir Muronetz, Regina Asryants, Pavel Semenyuk, Elena Schmalhausen and Luciano Saso

Volume 14 , Issue 22 , 2014

Page: [2520 - 2528] Pages: 9

DOI: 10.2174/1568026614666141203124057

Price: $65

Abstract

There are numerous reports on the role of oxidative stress in the origin of some neurodegenerative (Alzheimer’s and Parkinson’s) diseases; however, the information concerning molecular mechanisms of the observed effects is rather contradictory. This paper summarizes the review of our own works in this field and new experimental observations on the antioxidant action of some hydrophobic plant compounds. We discuss our hypothesis on the role of misfolded proteins in the regulation of the chaperone system involved in the genesis of amyloid neurodegenerative (prion and Alzheimer’s) diseases, briefly describe the role of modification of the glycolytic enzyme glyceraldehyde-3-phosphate dehydrogenase in the inhibition of glycolysis and induction of the apoptosis of nerve cells, and suggest possible ways of the use of hydrophobic plant antioxidants for the prevention of amyloid transformation of proteins and other neurodegenerative processes.

Keywords: Hydrophobic plant antioxidants, Glyceraldehyde-3-phosphate dehydrogenase, Oxidative stress, 2-hydroxypropylbeta- cyclodextrin.

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