摘要
动脉粥样硬化是一种慢性炎症性疾病,导致心血管疾病的发病率和死亡率在世界范围内处于高水平。越来越多的证据表明,体液和细胞免疫反应是人类动脉粥样硬化发展的重要组成部分。自从最近十年,自身抗体已被确定为心血管疾病的活性介质,有的呈现保护作用而作为致动脉粥样硬化的因素。这篇综述呈现了最相关的自身抗体在急性冠状动脉综合征,中风和其他心肌病中各自的心血管预后价值以及其在动脉粥样硬化形成中潜在的病理生理意义。在自动抗体的作用机制中,可以看出他们通常调节先天免疫系统对前或抗发炎的反应和/或影响基础心率的调节。提高认识自动抗体的功能特性,从而发展针对先天免疫系统或抗原表位结合位点的新治疗方法。一些自动抗体已被报道是不良疾病的独立预后因素。除了常规的危险因素,这些自身抗体可能是有用的生物标志物,以增加心血管分类工具的敏感性和特异性。
关键词: 动脉粥样硬化,自身抗体,自身免疫性疾病,心肌疾病,心血管疾病
Current Drug Targets
Title:Auto-Antibodies As Possible Markers and Mediators of Ischemic, Dilated, and Rhythmic Cardiopathies
Volume: 16 Issue: 4
Author(s): Nathalie Satta and Nicolas Vuilleumier
Affiliation:
关键词: 动脉粥样硬化,自身抗体,自身免疫性疾病,心肌疾病,心血管疾病
摘要: Atherosclerosis is a chronic inflammatory disease leading to cardiovascular diseases responsible for a high level of morbidity and mortality worldwide. Increasing evidence tends to hold that humoral and cellular immune responses are a key component of human atherosclerosis development. Since the last decade, auto-antibodies have been identified as active mediators of cardiovascular disease, some presenting protective effects whereas others act as proatherogenic factors. This review presents an overview of the most relevant auto-antibodies with regards to their respective cardiovascular prognostic value in acute coronary syndrome, stroke and other cardiomyopathies, and their potential pathophysiologic implication in atherogenesis. Insights in the mechanisms of action of auto-antibodies show that they commonly modulate the innate immune system towards a pro- or anti-inflammatory response and/or affect the regulation of basal heart rate. The increased understanding of the auto-antibodies functional properties has led to the development of new therapeutic approaches targeting the innate immune system or the epitope-binding site. Some of these auto-antibodies have been reported to be independent prognostic factors of poor disease outcome. In addition to conventional risk factors, these autoantibodies could be helpful biomarkers to increase the sensitivity and specificity of the cardiovascular stratification tools.
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Cite this article as:
Nathalie Satta and Nicolas Vuilleumier , Auto-Antibodies As Possible Markers and Mediators of Ischemic, Dilated, and Rhythmic Cardiopathies, Current Drug Targets 2015; 16 (4) . https://dx.doi.org/10.2174/1389450115666141125122416
DOI https://dx.doi.org/10.2174/1389450115666141125122416 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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