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Current Molecular Imaging (Discontinued)

Editor-in-Chief

ISSN (Print): 2211-5552
ISSN (Online): 2211-5544

Molecular Imaging in Optical Coherence Tomography

Author(s): Scott P. Mattison, Wihan Kim, Jesung Park and Brian E. Applegate

Volume 3, Issue 2, 2014

Page: [88 - 105] Pages: 18

DOI: 10.2174/2211555203666141117233442

Price: $65

Abstract

Optical coherence tomography (OCT) is a medical imaging technique that provides tomographic images at micron scales in three dimensions and high speeds. The addition of molecular contrast to the available morphological image holds great promise for extending OCT’s impact in clinical practice and beyond. Fundamental limitations prevent OCT from directly taking advantage of powerful molecular processes such as fluorescence emission and incoherent Raman scattering. A wide range of approaches is being researched to provide molecular contrast to OCT. Here we review those approaches with particular attention to those that derive their molecular contrast directly from modulation of the OCT signal. We also provide a brief overview of the multimodal approaches to gaining molecular contrast coincident with OCT.

Keywords: Fluoresence imaging, magnetomotive, molecular imaging, optical coherence tomography, photothermal, pump-probe.


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