Abstract
Cyclodextrins (CDs) offer a potential solution to delivery of hydrophobic drugs. Cyclodextrins are capable of hydrophobic drug binding due to their unique property of possessing a hydrophobic interior cavity and a hydrophilic exterior. When hydrophobic drugs are complexed with CD molecules a significant increase has been reported in the bioavailability of those drugs in free solution. The unique characteristics of cyclodextrins facilitate in development of a hydrogel for delivering drugs with varying degree of aqueous solubility. Further, the mechanical and chemical properties of hydrogels can act as an excellent system in delivery of hydrophobic drugs through their gel matrix.
Keywords: Bioavailability, cyclodextrin-functionalized hydrogels, hydrophobic drugs.
Current Drug Therapy
Title:Cyclodextrin-Functionalized Hydrogels: A Novel Drug Delivery System for the Delivery of Hydrophobic Drugs
Volume: 9 Issue: 2
Author(s): Shailesh Thirumaleshwar and Parthasarthi K. Kulkarni
Affiliation:
Keywords: Bioavailability, cyclodextrin-functionalized hydrogels, hydrophobic drugs.
Abstract: Cyclodextrins (CDs) offer a potential solution to delivery of hydrophobic drugs. Cyclodextrins are capable of hydrophobic drug binding due to their unique property of possessing a hydrophobic interior cavity and a hydrophilic exterior. When hydrophobic drugs are complexed with CD molecules a significant increase has been reported in the bioavailability of those drugs in free solution. The unique characteristics of cyclodextrins facilitate in development of a hydrogel for delivering drugs with varying degree of aqueous solubility. Further, the mechanical and chemical properties of hydrogels can act as an excellent system in delivery of hydrophobic drugs through their gel matrix.
Export Options
About this article
Cite this article as:
Thirumaleshwar Shailesh and K. Kulkarni Parthasarthi, Cyclodextrin-Functionalized Hydrogels: A Novel Drug Delivery System for the Delivery of Hydrophobic Drugs, Current Drug Therapy 2014; 9 (2) . https://dx.doi.org/10.2174/1574885509666141117215954
DOI https://dx.doi.org/10.2174/1574885509666141117215954 |
Print ISSN 1574-8855 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-3903 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Potential Applications of Venom Peptides as Anti-Thrombotic Agents for Management of Arterial and Deep-Vein Thrombosis
Protein & Peptide Letters Pharmacokinetic Study of Amlodipine in Human Urine Using On-Line Coupled Isotachophoresis-Capillary Zone Electrophoresis with Diode Array Detection
Current Pharmaceutical Analysis Atrial Macroreentry in Congenital Heart Disease
Current Cardiology Reviews “Virostatics” as a Potential New Class of HIV Drugs
Current Pharmaceutical Design The Utility of Emerging Biomarkers and Imaging for Assessment of Cardiovascular Risk
Current Vascular Pharmacology Acknowledgements
Current Cardiology Reviews Neurovascular Mechanisms of Hypertension in Pregnancy
Current Neurovascular Research Breath Holding Index and Arterial Stiffness as Markers of Vascular Aging
Current Aging Science The Effect of Alcohol on Gastrointestinal Motility
Reviews on Recent Clinical Trials Optimal Management of Hypertension in patients with Ischemic Heart Disease
Cardiovascular & Hematological Agents in Medicinal Chemistry Central Blood Pressure and End-organ Damage
Current Hypertension Reviews Radionuclides Used in Nuclear Medicine Therapy – From Production to Dosimetry
Current Medical Imaging Sodium Ion Transporters as New Therapeutic Targets in Heart Failure
Cardiovascular & Hematological Agents in Medicinal Chemistry Structural Systems Pharmacology: A New Frontier in Discovering Novel Drug Targets
Current Drug Targets Statins in Aortic Stenosis
Current Pharmaceutical Design Targeting Neurotrophin Receptors in the Central Nervous System
CNS & Neurological Disorders - Drug Targets Salvianolic Acid B Inhibits Atherogenesis of Vascular Cells through Induction of Nrf2-dependent Heme Oxygenase-1
Current Medicinal Chemistry A Role for Insulin on L-Arginine Transport in Fetal Endothelial Dysfunction in Hyperglycaemia
Current Vascular Pharmacology Therapeutic Potential of microRNA Modulation in Pulmonary Arterial Hypertension
Current Vascular Pharmacology Tissue Plasminogen Activator Prevents Restoration of Tight Junction Proteins Through Upregulation of Angiopoietin-2
Current Neurovascular Research