PDE-5抑制剂：临床要点

Title:PDE-5 Inhibitors: Clinical Points

Volume: 16 Issue: 5

Author(s): Michael Doumas, Antonios Lazaridis, Niki Katsiki and Vasilios Athyros

Affiliation:

关键词: 心血管危险，勃起功能障碍，女性性功能障碍，磷酸二酯酶-5抑制剂，西地那非，他达拉非，伐地那非

摘要: Erectile dysfunction is usually of vascular origin and is frequently encountered in men with cardiovascular disease. The introduction of phosphodiesterase-5 inhibitors has revolutionized the management of patients with erectile dysfunction. Currently available phosphodiesterase-5 inhibitors have distinct pharmacokinetic and pharmacodynamic properties, thus permitting for tailoring sexual therapy according to patient characteristics and needs. Phosphodiesterase-5 inhibitors possess vasorelaxing properties and exert systemic hemodynamic effects, which need to be taken into account when other cardiovascular drugs are co-administered. Special caution is needed with alpha-blockers, while the co-administration with nitrates is contra-indicated due to the risk of life-threatening hypotension. This review presents the advent of sexual therapy, describes the mechanism of action and the specific characteristics of commercially available phosphodiesterase-5 inhibitors, summarizes the efficacy and safety of these drugs with special emphasis on the cardiovascular system, and discusses the clinical criteria used for the selection of each drug for the individual patient.

Cite this article as:

Michael Doumas, Antonios Lazaridis, Niki Katsiki and Vasilios Athyros , PDE-5 Inhibitors: Clinical Points, Current Drug Targets 2015; 16 (5) . https://dx.doi.org/10.2174/1389450115666141111111301