摘要
α-突触核蛋白(α-syn)聚集是许多神经退行性疾病的神经病理学特点,全部被统称为共核蛋白。对于这些疾病目前没有诊断前方法。虽然这些成分被描述为潜在的α-syn聚集配体,但是目前还没有可利用的α-syn 聚集的特殊PET放射性示踪剂。在缺少其它特定候选者的情况下,[18F]BF227已经被提出作为一种α-synPET放射性示踪剂。我们首次在此提出放射性示踪剂应用于快速蛋白病小鼠模型,在脑干和丘脑中显示α-syn沉积物。 我们的体内和体外研究显示 [18F]BF227 没有与α-syn 聚合物结合。这些结果强调[18F]BF227 PET没有合适这种实验蛋白的特征,论证发展的替代α-syn PET 指示剂的必要性。
关键词: α-突触核蛋白,大脑,神经影像,小动物PET,共核蛋白
Current Alzheimer Research
Title:Binding of the PET Radiotracer [18F]BF227 Does not Reflect the Presence of Alpha-Synuclein Aggregates in Transgenic Mice
Volume: 11 Issue: 10
Author(s): Elise Levigoureux, Sophie Lancelot, Caroline Bouillot, Fabien Chauveau, Mathieu Verdurand, Jeremy Verchere, Thierry Billard, Thierry Baron and Luc Zimmer
Affiliation:
关键词: α-突触核蛋白,大脑,神经影像,小动物PET,共核蛋白
摘要: Alpha-synuclein (α-syn) aggregation is a neuropathological hallmark of many neurodegenerative diseases, collectively termed synucleinopathies. There is currently no pre-mortem diagnosis tool for these diseases. Although some compounds have been described as potential ligands for α-syn aggregates, no specific PET radiotracer of aggregated α-syn is currently available. Recently, [18F]BF227 has been proposed as an α-syn PET radiotracer in the absence of other specific candidates. We proposed here, for the first time, to use this radiotracer in an accelerated mouse model of synucleinopathy presenting α-syn depositions in brainstem and thalamus. Our in vivo and in vitro studies showed that [18F]BF227 does not bind to α-syn aggregates. These results highlight the fact that [18F]BF227 PET has no suitable characteristics for monitoring this experimental synucleinopathy, justifying the need to develop alternative α-syn PET radiotracers.
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Elise Levigoureux, Sophie Lancelot, Caroline Bouillot, Fabien Chauveau, Mathieu Verdurand, Jeremy Verchere , Thierry Billard, Thierry Baron and Zimmer Luc, Binding of the PET Radiotracer [18F]BF227 Does not Reflect the Presence of Alpha-Synuclein Aggregates in Transgenic Mice, Current Alzheimer Research 2014; 11 (10) . https://dx.doi.org/10.2174/1567205011666141107154201
DOI https://dx.doi.org/10.2174/1567205011666141107154201 |
Print ISSN 1567-2050 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5828 |
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