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Mini-Reviews in Medicinal Chemistry


ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Synthesis and Biological Activity of Substituted-4,5,6,7-tetrahydrothieno Pyridines: A Review

Author(s): Jaiprakash N. Sangshetti, Abhay S. Zambare, Firoz A. Kalam Khan, Indrajeet Gonjari and Zahid Zaheer

Volume 14, Issue 12, 2014

Page: [988 - 1020] Pages: 33

DOI: 10.2174/1389557514666141106131425

Price: $65


4,5,6,7-Tetrahydrothieno pyridine is an important class of heterocyclic nucleus. Various 4,5,6,7-tetrahydrothieno pyridine derivatives have been synthesized and evaluated for various biological activities in different models with desired findings. Some analogs have shown potent biological activities and may be considered as lead molecule for the development of future drugs. Number of drug molecules are available in the market and many molecules are in clinical development containing 4,5,6,7-tetrahydrothieno pyridine nucleus as an important core. This review is an attempt to organize the chemical and biological aspects of 4,5,6,7-tetrahydrothieno pyridine analogs reported in last 20 year to till date. Review mainly focuses on the important role of the core in synthesis of drug or drug intermediates giving emphasis on synthetic schemes and biological activities of the different 4,5,6,7-tetrahydrothieno pyridine analogs.

Keywords: 4, 5, 6, 7-Tetrahydrothieno pyridine, biological activities, lead molecules, clinical development.

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