A Tandem and Domino Protocol for Synthesis of Chromeno-, Pyrano- and Quinolinofused Spiro[pyrazolo[3,4-b]pyridine-indolines]

Title:A Tandem and Domino Protocol for Synthesis of Chromeno-, Pyrano- and Quinolinofused Spiro[pyrazolo[3,4-b]pyridine-indolines]

Volume: 18 Issue: 19

Author(s): Sunil K. Gupta, Anand K. Arya, Sarita Khandelwal and Mahendra Kumar

Affiliation:

Keywords: Multicomponent domino reaction, spirooxindole, pyrazolo[3, 4-b]pyridine, pyrazolochromenopyridine, pyrazolopyranopyridine, pyrazoloquinolinopyridine.

Abstract: An efficient tandem and domino protocol for the synthesis of chromeno-, pyrano-, and quinolino- fused spiro[pyrazolo[3,4- b]pyridine-indolines] has been developed. The present method involves one-pot pseudo five-component reaction of hydrazine hydrate and ethyl acetoacetate with isatin, malonitrile/ cyclic β-diketones and ammonium acetate/ primary aromatic amines in ethanol without using catalyst.

Cite this article as:

Gupta K. Sunil, Arya K. Anand, Khandelwal Sarita and Kumar Mahendra, A Tandem and Domino Protocol for Synthesis of Chromeno-, Pyrano- and Quinolinofused Spiro[pyrazolo[3,4-b]pyridine-indolines], Current Organic Chemistry 2014; 18(19) . https://dx.doi.org/10.2174/138527281819141028114753