Abstract
The Barton-McCombie reaction (B-M reaction) is deoxygenation of aliphatic alcohols via thioacylation followed by a radical cleavage. Variations of the reactions may utilize different thioacyl fragments and hydrogen sources. In this review article, however, we have focused on the applications of this reaction as a mild and functional group tolerant method in deoxygenation step in total syntheses of some well recognized natural products.
Keywords: Barton-McCombie reaction, deoxygenation, free-radical reaction, hydroxyl group, natural product, tin hydrid, total syntheses, xanthate.
Current Organic Synthesis
Title:Applications of Barton-McCombie Reaction in Total Syntheses
Volume: 11 Issue: 6
Author(s): Majid M. Heravi, Atefe Bakhtiari and Zeinab Faghihi
Affiliation:
Keywords: Barton-McCombie reaction, deoxygenation, free-radical reaction, hydroxyl group, natural product, tin hydrid, total syntheses, xanthate.
Abstract: The Barton-McCombie reaction (B-M reaction) is deoxygenation of aliphatic alcohols via thioacylation followed by a radical cleavage. Variations of the reactions may utilize different thioacyl fragments and hydrogen sources. In this review article, however, we have focused on the applications of this reaction as a mild and functional group tolerant method in deoxygenation step in total syntheses of some well recognized natural products.
Export Options
About this article
Cite this article as:
Heravi M. Majid, Bakhtiari Atefe and Faghihi Zeinab, Applications of Barton-McCombie Reaction in Total Syntheses, Current Organic Synthesis 2014; 11 (6) . https://dx.doi.org/10.2174/157017941106141023113539
DOI https://dx.doi.org/10.2174/157017941106141023113539 |
Print ISSN 1570-1794 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6271 |
Call for Papers in Thematic Issues
Exploring the Role of Chemical Graph Theory in Advancing Current Organic Synthesis
Organic synthesis is a fundamental discipline in chemistry, crucial for the creation of complex molecules with diverse applications in pharmaceuticals, materials science, and beyond. However, the process of designing efficient synthetic routes for target molecules remains challenging. Chemical graph theory, a branch of theoretical chemistry, offers powerful tools for understanding ...read more
Photoswitches for Molecular Recognition
This Special Issue would cover the hot topics on synthesis and chemical and photophysical characterization of new photoswitchable derivatives and their applications on molecular recognition of metabolites and biological active compounds, both in physiological medium and in living cells. Photoswitches are compounds that can change their conformation or properties in ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Emerging Role of Cetuximab in the Treatment of Colorectal Cancer
Recent Patents on Anti-Cancer Drug Discovery Adoptive Immunotherapy for B-cell Malignancies Using CD19- Targeted Chimeric Antigen Receptor T-Cells: A Systematic Review of Efficacy and Safety
Current Medicinal Chemistry The Application of Chitosan and Its Derivatives as Nanosized Carriers for the Delivery of Chemical Drugs and Genes or Proteins
Current Drug Targets Antiviral Drugs that Target Cellular Proteins May Play Major Roles in Combating HIV Resistance
Current Pharmaceutical Design Schizophrenia: A Systematic Review of the Disease State, Current Therapeutics and their Molecular Mechanisms of Action
Current Medicinal Chemistry Integrative Control of Gastrointestinal Motility by Nitric Oxide
Current Medicinal Chemistry Recent Advances in Endocrine Metabolic Immune Disorders Drug Targeting: An Editorial Overview
Endocrine, Metabolic & Immune Disorders - Drug Targets Endocannabinoid System: A Multi-Facet Therapeutic Target
Current Clinical Pharmacology Hypertension in the Elderly: An Evidence-based Review
Current Pharmaceutical Design Atrial Fibrillation in Acute St-Elevation Myocardial Infarction: Clinical and Prognostic Features
Current Cardiology Reviews Coagulation and Sepsis
Endocrine, Metabolic & Immune Disorders - Drug Targets Rabbit Models of Ocular Diseases: New Relevance for Classical Approaches
CNS & Neurological Disorders - Drug Targets Therapeutic Challenges in Neuroendocrine Tumors
Anti-Cancer Agents in Medicinal Chemistry Screening, Evaluation, and Early Management of Acute Aortic Dissection in the ED
Current Cardiology Reviews Benefits of SGLT2 Inhibitors Beyond Glycemic Control – A Focus on Metabolic, Cardiovascular and Renal Outcomes
Current Diabetes Reviews Catechol-O-Methyltransferase (COMT)-Mediated Methylation Metabolism of Endogenous Bioactive Catechols and Modulation by Endobiotics and Xenobiotics: Importance in Pathophysiology and Pathogenesis
Current Drug Metabolism Thalidomide in Multiple Myeloma
Current Pharmaceutical Biotechnology Nitric Oxide and Dietary Factors: Part II Cholesterol, Fat, Amino Acids,Proteins and Carbohydrate
Vascular Disease Prevention (Discontinued) Transfusion-related Acute Lung Injury: An Overview
Current Pharmaceutical Design Monoclonal Antibodies in the Treatment of Systemic Lupus Erythematosus
Current Drug Targets