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Current Cancer Drug Targets


ISSN (Print): 1568-0096
ISSN (Online): 1873-5576

MicroRNA-34 Family, Mechanisms of Action in Cancer: A Review

Author(s): Hamidreza Maroof, Ali Salajegheh, Robert A. Smith and Alfred K.-Y. Lam

Volume 14, Issue 8, 2014

Page: [737 - 751] Pages: 15

DOI: 10.2174/1568009614666141020100337

Price: $65


Altered expression of the microRNA-34 family has been determined to be involved in the pathogenesis of many cancers. In this review, the current knowledge of the cancer-related mechanisms in relation to the modulatory effects of microRNA-34 family were analysed. Expression analysis of the microRNA-34 family has suggested that its members play significant roles in many aspects of cancer biology including proliferation, invasion/metastasis, apoptosis/cell survival, cell cycle/cell growth, migration, senescence/aging, angiogenesis, epigenetic silencing and methylation by regulation of the expression of their target genes. Thus, microRNA-34 family members could act as prognostic markers and therapeutic targets in human cancers.

Keywords: Cancer, carcinoma, miR-34a, miR-34b, miR-34c, tumour suppressor gene, miRNA-34 family.

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