Regulatory T Cells and Tolerogenic Dendritic Cells as Critical Immune Modulators in Atherogenesis

Title:Regulatory T Cells and Tolerogenic Dendritic Cells as Critical Immune Modulators in Atherogenesis

Volume: 21 Issue: 9

Author(s): Naoto Sasaki, Tomoya Yamashita, Kazuyuki Kasahara, Masafumi Takeda and Ken-ichi Hirata

Affiliation:

Keywords: Atherosclerosis, immune system, inflammation, regulatory T cells, tolerogenic dendritic cells.

Abstract: Innate and adaptive immunity has been shown to be critically involved in the pathogenesis of atherosclerosis. In particular, immune suppression mediated by regulatory T cells (Tregs) or tolerogenic dendritic cells (DCs) serves as a vital mechanism for regulating pathogenic chronic inflammation in atherogensis, suggesting that promotion of endogenous regulatory immune responses could be a possible therapeutic approach to suppress atherosclerotic disease. In this review, we discuss the possible role of Tregs and tolerogenic DCs in the prevention of atherosclerosis and the promising strategies to prevent or cure atherosclerotic disease by modulating regulatory immune responses mediated by these suppressor cells.

Cite this article as:

Sasaki Naoto, Yamashita Tomoya, Kasahara Kazuyuki, Takeda Masafumi and Hirata Ken-ichi, Regulatory T Cells and Tolerogenic Dendritic Cells as Critical Immune Modulators in Atherogenesis, Current Pharmaceutical Design 2015; 21 (9) . https://dx.doi.org/10.2174/1381612820666141013142518