Synthesis and Biological Activity of Acylthiourea Derivatives Contain 1,2,3-thiadiazole and 1,3,4-thiadiazole

Title:Synthesis and Biological Activity of Acylthiourea Derivatives Contain 1,2,3-thiadiazole and 1,3,4-thiadiazole

Volume: 12 Issue: 4

Author(s): Ming-Yan Yang, Wen Zhao, Zhao-Hui Sun, Cheng-Xia Tan, Jian-Quan Weng and Xing-Hai Liu

Affiliation:

Keywords: 1, 2, 3-thiadiazole, 1, 3, 4-thiadiazole, bioactivity, synthesis, thiourea.

Abstract: In order to investigate the biological activity of novel thiourea compounds, some novel 1,2,3- thiadiazole derivatives containing 1,3,4-thiadiazole were synthesized under phase transfer catalyzed condition( PEG-600)by multi-step reactions. The chemical structures of all compounds were established by ¹H NMR, FTIR, MS, and elemental analysis, and some of these compounds were investigated for fungicidal activity and plant growth regulatory activity. The bioassay results indicated that some of these compound exhibited moderate activities.

Cite this article as:

Yang Ming-Yan, Zhao Wen, Sun Zhao-Hui, Tan Cheng-Xia, Weng Jian-Quan and Liu Xing-Hai, Synthesis and Biological Activity of Acylthiourea Derivatives Contain 1,2,3-thiadiazole and 1,3,4-thiadiazole, Letters in Drug Design & Discovery 2015; 12 (4) . https://dx.doi.org/10.2174/1570180811666141010000435