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Combinatorial Chemistry & High Throughput Screening


ISSN (Print): 1386-2073
ISSN (Online): 1875-5402

Defensins and Other Antimicrobial Peptides: A Historical Perspective and an Update

Author(s): Tomas Ganz

Volume 8, Issue 3, 2005

Page: [209 - 217] Pages: 9

DOI: 10.2174/1386207053764594

Price: $65


Antimicrobial peptides are effectors of innate immunity in phagocytes, body fluids and epithelia. In mammals, defensins, peptides with a characteristic six-cysteine framework, are particularly abundant and widely distributed in various animal species and tissues. The first part of this review provides a historical overview of the ideas that led to the current state-of-the-art in antimicrobial peptides, and the second part is an update on mammalian defensins and their role in host defense to infections.

Keywords: history, membrane interactions, peptide structure

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