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Current Pharmaceutical Biotechnology


ISSN (Print): 1389-2010
ISSN (Online): 1873-4316

Further in vitro Evaluation of Antimicrobial Activity of the Marine Sesquiterpene Hydroquinone Avarol

Author(s): Boris Pejin, Carmine Iodice, Giuseppina Tommonaro, Bojana Stanimirovic, Ana Ciric, Jasmina Glamoclija, Milos Nikolic, Salvatore De Rosa and Marina Sokovic

Volume 15, Issue 6, 2014

Page: [583 - 588] Pages: 6

DOI: 10.2174/138920101506140910152253

Price: $65


This work extends in vitro screening of antimicrobial activity of the sesquiterpene hydroquinone avarol, a main secondary metabolite of the Mediterranean sponge species Dysidea avara. The antimicrobial activity was in part evaluated by microdilution method against selected bacterial and fungal strains. Additionally, the screening included evaluation of anti-quorum sensing (anti-QS) effects. At a different extent avarol was proven to be active against all the microorganisms tested (MIC 0.002-0.008 mg/mL and MBC 0.004-0.016 mg/mL; MIC 0.004-0.015 mg/mL and MFC 0.008-0.030 mg/mL; respectively). This marine natural product also showed moderate anti-QS effects, reducing Pseudomonas aeruginosa PAO1 biofilm formation (75%), its twitching and protrusions motilities as well as pyocianin production (39%). According to the best of our knowledge, this is the first report both on avarol anti Gram-negative bacterial activity and anti-QS effects.

Keywords: Anti-quorum sensing effects, Dysidea avara, Gram-negative bacteria, natural product, Pseudomonas aeruginosa PAO1.

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