Further in vitro Evaluation of Antimicrobial Activity of the Marine Sesquiterpene Hydroquinone Avarol

Title:Further in vitro Evaluation of Antimicrobial Activity of the Marine Sesquiterpene Hydroquinone Avarol

Volume: 15 Issue: 6

Author(s): Boris Pejin, Carmine Iodice, Giuseppina Tommonaro, Bojana Stanimirovic, Ana Ciric, Jasmina Glamoclija, Milos Nikolic, Salvatore De Rosa and Marina Sokovic

Affiliation:

Keywords: Anti-quorum sensing effects, Dysidea avara, Gram-negative bacteria, natural product, Pseudomonas aeruginosa PAO1.

Abstract: This work extends in vitro screening of antimicrobial activity of the sesquiterpene hydroquinone avarol, a main secondary metabolite of the Mediterranean sponge species Dysidea avara. The antimicrobial activity was in part evaluated by microdilution method against selected bacterial and fungal strains. Additionally, the screening included evaluation of anti-quorum sensing (anti-QS) effects. At a different extent avarol was proven to be active against all the microorganisms tested (MIC 0.002-0.008 mg/mL and MBC 0.004-0.016 mg/mL; MIC 0.004-0.015 mg/mL and MFC 0.008-0.030 mg/mL; respectively). This marine natural product also showed moderate anti-QS effects, reducing Pseudomonas aeruginosa PAO1 biofilm formation (75%), its twitching and protrusions motilities as well as pyocianin production (39%). According to the best of our knowledge, this is the first report both on avarol anti Gram-negative bacterial activity and anti-QS effects.

Cite this article as:

Pejin Boris, Iodice Carmine, Tommonaro Giuseppina, Stanimirovic Bojana, Ciric Ana, Glamoclija Jasmina, Nikolic Milos, Rosa De Salvatore and Sokovic Marina, Further in vitro Evaluation of Antimicrobial Activity of the Marine Sesquiterpene Hydroquinone Avarol, Current Pharmaceutical Biotechnology 2014; 15 (6) . https://dx.doi.org/10.2174/138920101506140910152253