Pd/C-catalyzed Synthesis of (E)-2-arylmethylideneindolin-3-ols Under Ultrasound: Their Initial Evaluation as Potential Anti-proliferative Agents

Title:Pd/C-catalyzed Synthesis of (E)-2-arylmethylideneindolin-3-ols Under Ultrasound: Their Initial Evaluation as Potential Anti-proliferative Agents

Volume: 12 Issue: 2

Author(s): Ponugubati Radhakrishna Murthi, Namburi Suresh, Chekuri Sharmila Rani, Mandava Venkata Basaveswara Rao and Manojit Pal

Affiliation:

Keywords: Cancer, coupling, hydroamination, indolin-3-ol, Pd/C.

Abstract: (E)-2-Arylmethylideneindolin-3-ol derivatives have been explored as new and potential anti-proliferative agents. Synthesis of these compounds was carried out by using a Pd/C-catalyzed alternative and one-pot method involving C-C coupling of 1-(2-(p-tosylamino)phenyl)prop-2-yn-1-ol with a range of iodoarenes followed by intramolecular hydroamination in the same pot. The reaction proceeded faster when performed under ultrasound irradiation. All these compounds showed selective growth inhibition of MDA-MB 231 cancer cells.

Cite this article as:

Murthi Radhakrishna Ponugubati, Suresh Namburi, Rani Sharmila Chekuri, Rao Venkata Basaveswara Mandava and Pal Manojit, Pd/C-catalyzed Synthesis of (E)-2-arylmethylideneindolin-3-ols Under Ultrasound: Their Initial Evaluation as Potential Anti-proliferative Agents, Letters in Drug Design & Discovery 2015; 12 (2) . https://dx.doi.org/10.2174/1570180811666140819224103