Abstract
Tuberculosis is essentially a curable disease but inspite of a WHO approved DOTS therapy, it still continues to ravage mankind. This situation is exacerbated by long course of chemotherapy, increasing drug resistance and co-emergence with HIV. The TB drug pipeline remained stagnant for a long time with no new drug approved till FDA approval for Bedaquiline. This situation has now improved with a number of agents in pre-clinical and clinical development against M. tuberculosis. In this review, we are focusing on some of the newer drugs in discovery and preclinical development against M. tuberculosis.
Keywords: Clinical strains, drugs, MIC, Mycobacterium, pre-clinical development, tuberculosis.
Current Respiratory Medicine Reviews
Title:Current Approaches for New TB Drugs
Volume: 10 Issue: 2
Author(s): Shilpika Pandey, Isha Soni, Neha Topno, Arunava Dasgupta and Sidharth Chopra
Affiliation:
Keywords: Clinical strains, drugs, MIC, Mycobacterium, pre-clinical development, tuberculosis.
Abstract: Tuberculosis is essentially a curable disease but inspite of a WHO approved DOTS therapy, it still continues to ravage mankind. This situation is exacerbated by long course of chemotherapy, increasing drug resistance and co-emergence with HIV. The TB drug pipeline remained stagnant for a long time with no new drug approved till FDA approval for Bedaquiline. This situation has now improved with a number of agents in pre-clinical and clinical development against M. tuberculosis. In this review, we are focusing on some of the newer drugs in discovery and preclinical development against M. tuberculosis.
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Pandey Shilpika, Soni Isha, Topno Neha, Dasgupta Arunava and Chopra Sidharth, Current Approaches for New TB Drugs, Current Respiratory Medicine Reviews 2014; 10 (2) . https://dx.doi.org/10.2174/1573398X10666140813201210
DOI https://dx.doi.org/10.2174/1573398X10666140813201210 |
Print ISSN 1573-398X |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6387 |
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