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Current Bioactive Compounds


ISSN (Print): 1573-4072
ISSN (Online): 1875-6646

Spectroscopic Characterization of a Pyridine Alkaloid from an Endophytic Strain of the Fusarium incarnatum-equiseti Species Complex

Author(s): Monica Scognamiglio, Rosario Nicoletti, Severina Pacifico, Brigida D'Abrosca and Antonio Fiorentino

Volume 10, Issue 3, 2014

Page: [196 - 200] Pages: 5

DOI: 10.2174/1573407210666140716163923

Price: $65


Chemical investigation of the endophytic strain A1021B ascribed to the Fusarium incarnatum-equiseti species complex led to the isolation of a novel pyridine alkaloid related to fusaric acid. The structure was elucidated by 1D and 2D NMR experiments (1H, 13C, COSY, HSQC, CIGAR-HMBC, H2BC). The compound induced cytotoxic effects on six human cancer cell lines (SK-N-BE(2)-C, SH-SY5Y, A549, HepG2, HeLa, and MCF-7).

Keywords: Cytotoxicity, endophyte, fusarinol, Fusarium incarnatum-equiseti, NMR analysis.

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