Spectroscopic Characterization of a Pyridine Alkaloid from an Endophytic Strain of the Fusarium incarnatum-equiseti Species Complex

Title:Spectroscopic Characterization of a Pyridine Alkaloid from an Endophytic Strain of the Fusarium incarnatum-equiseti Species Complex

Volume: 10 Issue: 3

Author(s): Monica Scognamiglio, Rosario Nicoletti, Severina Pacifico, Brigida D'Abrosca and Antonio Fiorentino

Affiliation:

Keywords: Cytotoxicity, endophyte, fusarinol, Fusarium incarnatum-equiseti, NMR analysis.

Abstract: Chemical investigation of the endophytic strain A1021B ascribed to the Fusarium incarnatum-equiseti species complex led to the isolation of a novel pyridine alkaloid related to fusaric acid. The structure was elucidated by 1D and 2D NMR experiments (¹H, ¹³C, COSY, HSQC, CIGAR-HMBC, H2BC). The compound induced cytotoxic effects on six human cancer cell lines (SK-N-BE(2)-C, SH-SY5Y, A549, HepG2, HeLa, and MCF-7).

Cite this article as:

Scognamiglio Monica, Nicoletti Rosario, Pacifico Severina, D'Abrosca Brigida and Fiorentino Antonio, Spectroscopic Characterization of a Pyridine Alkaloid from an Endophytic Strain of the Fusarium incarnatum-equiseti Species Complex, Current Bioactive Compounds 2014; 10(3) . https://dx.doi.org/10.2174/1573407210666140716163923