Abstract
Platelet Rich Plasma (PRP) and growth factors have had encouraging results in several surgical specialties. Their use in orthopaedics is increasing and has been trialed in fracture management, spinal fusion and tendon and ligament healing. Anterior cruciate ligament (ACL) injuries are a significant economic burden and often require surgical reconstruction. This review article used laboratory and clinical studies to evaluate the effectiveness of PRP and growth factors as an adjunct to ACL reconstruction. Overall, the results of studies to date have been disappointing especially given the success in other specialties. PRP has been relatively successful in improving vascularization within the tibial tunnel but less so in the femoral tunnels. The targeting of specific growth factors seems to show more promise than generic PRP injections with vascular endothelial growth factor (VEGF), platelet derived growth factor (PDGF) and transforming growth factor-beta (TGF-β) showing the most significant results in graft healing. Further trials are still required before a definitive conclusion can be reached.
Keywords: Anterior cruciate ligament, growth factors, platelet rich plasma, repair, surgical reconstruction, tissue engineering.
Current Stem Cell Research & Therapy
Title:Growth Factors and Platelet Rich Plasma in Anterior Cruciate Ligament Reconstruction
Volume: 10 Issue: 1
Author(s): Lianne Bissell, Saket Tibrewal, Varun Sahni and Wasim S. Khan
Affiliation:
Keywords: Anterior cruciate ligament, growth factors, platelet rich plasma, repair, surgical reconstruction, tissue engineering.
Abstract: Platelet Rich Plasma (PRP) and growth factors have had encouraging results in several surgical specialties. Their use in orthopaedics is increasing and has been trialed in fracture management, spinal fusion and tendon and ligament healing. Anterior cruciate ligament (ACL) injuries are a significant economic burden and often require surgical reconstruction. This review article used laboratory and clinical studies to evaluate the effectiveness of PRP and growth factors as an adjunct to ACL reconstruction. Overall, the results of studies to date have been disappointing especially given the success in other specialties. PRP has been relatively successful in improving vascularization within the tibial tunnel but less so in the femoral tunnels. The targeting of specific growth factors seems to show more promise than generic PRP injections with vascular endothelial growth factor (VEGF), platelet derived growth factor (PDGF) and transforming growth factor-beta (TGF-β) showing the most significant results in graft healing. Further trials are still required before a definitive conclusion can be reached.
Export Options
About this article
Cite this article as:
Bissell Lianne, Tibrewal Saket, Sahni Varun and Khan S. Wasim, Growth Factors and Platelet Rich Plasma in Anterior Cruciate Ligament Reconstruction, Current Stem Cell Research & Therapy 2015; 10 (1) . https://dx.doi.org/10.2174/1574888X09666140710102002
DOI https://dx.doi.org/10.2174/1574888X09666140710102002 |
Print ISSN 1574-888X |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-3946 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
The Inducible Effect of LBP on Maturation of Dendritic Cells and the Related Immune Signaling Pathways in Hepatocellular Carcinoma (HCC)
Current Drug Delivery Drug Nanocarriers and Functional Nanoparticles: Applications in Cancer Therapy
Current Drug Delivery NKT Cells: A Regulator in Both Innate and Acquired Immunity
Current Medicinal Chemistry - Anti-Inflammatory & Anti-Allergy Agents Computer-Aided Drug Design Applied to Secondary Metabolites as Anticancer Agents
Current Topics in Medicinal Chemistry Cerebral Arachidonate Cascade in Dementia: Alzheimers Disease and Vascular Dementia
Current Neuropharmacology Advancement in Obesity Management: Leptin and Adiponectin Patents
Recent Patents on Endocrine, Metabolic & Immune Drug Discovery Community-Acquired Pneumonia and Outcome: The Importance of Genetics
Current Respiratory Medicine Reviews Inflammatory Biomarkers in Peripheral Artery Disease: Diagnosis, Prognosis, and Therapeutic Challenges
Current Medicinal Chemistry Nano Conjugated PLGA-Chlorambucil: Synthesis In Vitro Anti Non- Hodgkin's Lymphoma Cellular Assay
Letters in Drug Design & Discovery Modulation Effects of Piracetam and Ginkgo biloba on the Cognitive and Working Memory Functions: Psychometric Study
Current Psychopharmacology Clopidogrel Resistance: Implications for Coronary Stenting
Current Pharmaceutical Design Synthesis, Structure and Antibacterial Evaluation of Some N-substituted 3-amino-5-hydroxy-4-phenyl-1H-pyrazole-1-carboxamides
Medicinal Chemistry Contribution of NRF2 in Gastrointestinal Protection from Oxidative Injury
Current Pharmaceutical Design Stevens Johnson Syndrome versus Jarisch Herxheimer Reaction in an HIV Positive Patient with Secondary Syphilis
Recent Patents on Inflammation & Allergy Drug Discovery Cardiovascular and Metabolic Effects of Ghrelin
Current Diabetes Reviews Interleukins Involved in Inflammatory Bowel Disease as New Therapeutic Targets
Current Immunology Reviews (Discontinued) CCR1 Chemokine Receptor Antagonist
Current Pharmaceutical Design Therapeutic Applications of Mesenchymal Stem Cells: A Comprehensive Review
Current Stem Cell Research & Therapy Mechanism of Cancer Drug Resistance and the Involvement of Noncoding RNAs
Current Medicinal Chemistry Hypogonadotrophic Hypogonadism in Type 2 Diabetes, Obesity and the Metabolic Syndrome
Current Molecular Medicine