Abstract
Enantioseparation of 2-chloromandelic acid enantiomers by ligand exchange chromatography was successfully carried out using chiral ionic liquids (CILs) containing imidazolium cation and L-Proline anion as chiral selectors. The main factors influencing resolution, such as alkyl chain length of CILs, concentrations of Cu2+ and CILs, pH of the mobile phase and temperature, were investigated. To better understand the enantioseparation process, some thermodynamical parameters were evaluated, and the results indicated that the chiral separation of 2-chloromandelic acid enantiomers was an enthalpy-controlled process.
Keywords: Chiral ionic liquids, ligand exchange, enantioseparation, 2-chloromandelic acid enantiomers, enthalpy-controlled process.
Current Analytical Chemistry
Title:Enantioseparation of 2-chloromandelic Acid Enantiomers by Ligand Exchange Chromatography Based on Chiral Ionic Liquids
Volume: 10 Issue: 4
Author(s): Yan Yue, Jingang Yu, Xinyu Jiang and Qiaoyue Deng
Affiliation:
Keywords: Chiral ionic liquids, ligand exchange, enantioseparation, 2-chloromandelic acid enantiomers, enthalpy-controlled process.
Abstract: Enantioseparation of 2-chloromandelic acid enantiomers by ligand exchange chromatography was successfully carried out using chiral ionic liquids (CILs) containing imidazolium cation and L-Proline anion as chiral selectors. The main factors influencing resolution, such as alkyl chain length of CILs, concentrations of Cu2+ and CILs, pH of the mobile phase and temperature, were investigated. To better understand the enantioseparation process, some thermodynamical parameters were evaluated, and the results indicated that the chiral separation of 2-chloromandelic acid enantiomers was an enthalpy-controlled process.
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Cite this article as:
Yue Yan, Yu Jingang, Jiang Xinyu and Deng Qiaoyue, Enantioseparation of 2-chloromandelic Acid Enantiomers by Ligand Exchange Chromatography Based on Chiral Ionic Liquids, Current Analytical Chemistry 2014; 10 (4) . https://dx.doi.org/10.2174/157341101004140701115108
DOI https://dx.doi.org/10.2174/157341101004140701115108 |
Print ISSN 1573-4110 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6727 |
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