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Mini-Reviews in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Medicinal Chemistry Discoveries among 1,3,5-Triazines: Recent Advances (2000-2013) as Antimicrobial, Anti-TB, Anti-HIV and Antimalarials

Author(s): Rahul V. Patel, Young-Soo Keum and Se Won Park

Volume 14, Issue 9, 2014

Page: [768 - 789] Pages: 22

DOI: 10.2174/1389557514666140622205904

Price: $65

Abstract

The chemistry and an extensive spectrum of biological activities of s-triazines have been examined since several decades and this heterocyclic core has received emerging consensus. This article aims to summarize recent advances (2000-2013) made towards the discovery of antimicrobial, antituberculosis, anti-HIV and antimalarial agents holding 1,3,5-triazine ring as a nucleus with the substitution of several types of nucleophiles. Molecular patterns associated with particular potency have been identified targeting several Gram-positive and Gram-negative bacteria and some fungal species, mycobacterium tuberculosis H37Rv, HIV type I and HIV type II, particularly, HIV-1I IIB and HIV- 1ROD strains as well as a variety of P. falciparum malarial strains as chloroquine-resistant K1, chloroquine-susceptible NF54, chloroquine-sensitive 3D7, P. falciparum (D6 clone), P. falciparum (W2 clone), cycloguanil-resistant FCR-3, chloroquine sensitive RKL2. The report will be of considerable interest to gain useful information for the furtherance of drug discovery with extended 1,3,5-triazine designs.

Keywords: Anti-TB activity, anti-HIV activity, antimalarial activity, antimicrobial activity, drug discovery, s-triazine.

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