Abstract
Non-invasive stimulation of the human brain to improve depressive symptoms is increasingly finding its way in clinical settings as a viable form of somatic treatment. Following successful modulation of neural excitability with subsequent antidepressant effects, neural polarization by administrating weak direct currents to the scalp has gained renewed interest. A new wave of basic and clinical studies seems to underscore the potential therapeutic value of direct current stimulation in the treatment of depression. Issues concerning the lack of mechanistic insights into the workings of modifying brain function through neural polarization and how this process translates to its antidepressant properties calls for additional research. The range of its clinical applicability has yet to be established.
Keywords: Depressive disorder, non-invasive brain stimulation, transcranial direct current stimulation, treatment.
CNS & Neurological Disorders - Drug Targets
Title:Current Directions in Non-Invasive Low Intensity Electric Brain Stimulation for Depressive Disorder
Volume: 13 Issue: 6
Author(s): Dennis J.L.G. Schutter and Alexander T. Sack
Affiliation:
- Department of Neurocognition, Faculty of Psychology and Neuroscience, Maastricht University, Universiteitssingel 40 East, 6229 ER Maastricht, The Netherlands.,Netherlands
Keywords: Depressive disorder, non-invasive brain stimulation, transcranial direct current stimulation, treatment.
Abstract: Non-invasive stimulation of the human brain to improve depressive symptoms is increasingly finding its way in clinical settings as a viable form of somatic treatment. Following successful modulation of neural excitability with subsequent antidepressant effects, neural polarization by administrating weak direct currents to the scalp has gained renewed interest. A new wave of basic and clinical studies seems to underscore the potential therapeutic value of direct current stimulation in the treatment of depression. Issues concerning the lack of mechanistic insights into the workings of modifying brain function through neural polarization and how this process translates to its antidepressant properties calls for additional research. The range of its clinical applicability has yet to be established.
Export Options
About this article
Cite this article as:
Schutter J.L.G. Dennis and Sack T. Alexander, Current Directions in Non-Invasive Low Intensity Electric Brain Stimulation for Depressive Disorder, CNS & Neurological Disorders - Drug Targets 2014; 13(6) . https://dx.doi.org/10.2174/1871527313666140612115123
DOI https://dx.doi.org/10.2174/1871527313666140612115123 |
Print ISSN 1871-5273 |
Publisher Name Bentham Science Publisher |
Online ISSN 1996-3181 |

- Author Guidelines
- Editorial Policies
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Allegations from Whistleblowers
- Publishing Ethics and Rectitude
- Increase Visibility Of Your Article
- Archiving Policies
- Reviewer Guidelines
- Guest Editor Guidelines
- Board Recruitment Workflow
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Announcements
- Forthcoming Thematic Issues
Related Articles
-
Antimicrobial Peptide rBPI21: A Translational Overview from Bench to Clinical Studies
Current Protein & Peptide Science Linezolid in Children: Recent Patents and Advances
Recent Patents on Anti-Infective Drug Discovery Bacterial Siderophores and Their Potential Applications: A Review
Current Molecular Pharmacology Nanoemulsion: A Novel Eon in Cancer Chemotherapy
Mini-Reviews in Medicinal Chemistry Peroxisome Proliferator-Activated Receptor-α Activation Protects Brain Capillary Endothelial Cells from Oxygen-Glucose Deprivation-Induced Hyperpermeability in the Blood-Brain Barrier
Current Neurovascular Research Dendrimers as Novel Systems for Delivery of Neuropharmaceuticals to the Brain
CNS & Neurological Disorders - Drug Targets Kynurenine Pathway in Schizophrenia: Pathophysiological and Therapeutic Aspects
Current Pharmaceutical Design Pro-Stimulatory Role of Methemoglobin in Inflammation Through Hemin Oxidation and Polymerization
Inflammation & Allergy - Drug Targets (Discontinued) Detection of Antibiotic Resistance Genes Among Multiple Drug Resistant Pseudomonas Aeruginosa Isolated from Clinical Sources in Selected Health Institutions in Kwara State
Infectious Disorders - Drug Targets Intravenous Immunoglobulin (IVIG) in Rheumatologic Diseases: A Review of its Mechanism of Action
Current Rheumatology Reviews Aβ Oligomers Induce Glutamate Release from Hippocampal Neurons
Current Alzheimer Research Targeting Matrix Metalloproteinases in Acute Inflammatory Shock Syndromes
Combinatorial Chemistry & High Throughput Screening Amyloid β Accumulation Assessed with <sup>11</sup>C-Pittsburgh Compound B PET and Postmortem Neuropathology
Current Alzheimer Research Nasal Drug Delivery System-Factors Affecting and Applications
Current Drug Therapy Patent Annotations
Recent Patents on CNS Drug Discovery (Discontinued) Aptamers: Molecular Tools for Medical Diagnosis
Current Topics in Medicinal Chemistry β-Amyloid Upregulates Intracellular Clusterin but not Secretory Clusterin in Primary Cultured Neurons and APP Mice
Current Alzheimer Research AIDS-Defining Illnesses: A Comparison Between Before and After Commencement of Highly Active Antiretroviral Therapy (HAART)
Current HIV Research Genetically Modified Viruses Vaccines by Design
Current Pharmaceutical Biotechnology Nanobiotechnology-based Drug Delivery in Brain Targeting
Current Pharmaceutical Biotechnology