Abstract
In the armamentarium of calcium channel blockers appropriately functionalized 3,4-dihydropyrimidin-2(1H)- ones have received considerable attention in recent past owing to their structural similarity with 1,4-dihydropyridine based drugs. In this review, we highlight detailed investigations in the calcium channel blocking and other activities of this category of compounds as well as trace their genesis from 1,4-dihydropyridine based drugs.
Keywords: Dihydropyridines, dihydropyrimidines, dihydropyrimidinones, calcium channel blockers, mitotic kinesin inhibitors, α-adrenergic receptor antagonists, structure- activity relationships
Mini-Reviews in Medicinal Chemistry
Title:Genesis of Dihydropyrimidinone Calcium Channel Blockers: Recent Progress in Structure-Activity Relationships and Other Effects
Volume: 9 Issue: 1
Author(s): K. Singh, D. Arora and S. Singh
Affiliation:
Keywords: Dihydropyridines, dihydropyrimidines, dihydropyrimidinones, calcium channel blockers, mitotic kinesin inhibitors, α-adrenergic receptor antagonists, structure- activity relationships
Abstract: In the armamentarium of calcium channel blockers appropriately functionalized 3,4-dihydropyrimidin-2(1H)- ones have received considerable attention in recent past owing to their structural similarity with 1,4-dihydropyridine based drugs. In this review, we highlight detailed investigations in the calcium channel blocking and other activities of this category of compounds as well as trace their genesis from 1,4-dihydropyridine based drugs.
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Cite this article as:
K. Singh, D. Arora and S. Singh , Genesis of Dihydropyrimidinone Calcium Channel Blockers: Recent Progress in Structure-Activity Relationships and Other Effects, Mini-Reviews in Medicinal Chemistry 2009; 9 (1) . https://dx.doi.org/10.2174/138955709787001686
DOI https://dx.doi.org/10.2174/138955709787001686 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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