Generic placeholder image

Current Topics in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1568-0266
ISSN (Online): 1873-4294

Recent Advances on the Enantioselective Synthesis of C-Nucleosides Inhibitors of Inosine Monophosphate Dehydrogenase (IMPDH)

Author(s): Pedro Merino, Mattia Ghirardello, Tomas Tejero, Ignacio Delso and Rosa Matute

Volume 14, Issue 10, 2014

Page: [1212 - 1224] Pages: 13

DOI: 10.2174/1568026614666140423095331

Price: $65

Abstract

This review will describe the recent advances in the synthesis of C-nucleosides with inhibitory activity of inosine monophosphate dehydrogenase (IMPDH), a key enzyme in the biosynthesis of guanine nucleotides. The review will cover synthetic approaches of structural analogues showing modifications in the furanose ring as well as in the heterocyclic base. Heterocyclic sugar nucleoside analogues in which the furanose ring has been replaced by a different heterocyclic ring including aza analogues, thioanalogues as well as dioxolanyl and isoxazolidinyl analogues are also considered.

Keywords: C-Nucleosides, enzyme inhibitors, heterocyclic nucleosides, IMPDH, thiazole, tiazofurin.

Graphical Abstract

Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy