Abstract
For more than 20 years there has been increasing interest in the development of novel therapies to raise levels of high-density lipoprotein cholesterol (HDL-C). However, well publicized failures of recent clinical trials of agents that raise HDL-C levels have stimulated considerable controversy with regard to the potential clinical utility of this therapeutic target. A number of classes of agents are currently under investigation with variable effects on HDL quantity and quality. These will be reviewed.
Keywords: Atherosclerosis, cardiovascular disease, HDL, lipids, risk factors.
Current Medicinal Chemistry
Title:New Drugs for HDL-C Disorders: The Beginning
Volume: 21 Issue: 25
Author(s): MyNgan Duong and Stephen J. Nicholls
Affiliation:
Keywords: Atherosclerosis, cardiovascular disease, HDL, lipids, risk factors.
Abstract: For more than 20 years there has been increasing interest in the development of novel therapies to raise levels of high-density lipoprotein cholesterol (HDL-C). However, well publicized failures of recent clinical trials of agents that raise HDL-C levels have stimulated considerable controversy with regard to the potential clinical utility of this therapeutic target. A number of classes of agents are currently under investigation with variable effects on HDL quantity and quality. These will be reviewed.
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Cite this article as:
Duong MyNgan and Nicholls J. Stephen, New Drugs for HDL-C Disorders: The Beginning, Current Medicinal Chemistry 2014; 21 (25) . https://dx.doi.org/10.2174/0929867321666140414104130
DOI https://dx.doi.org/10.2174/0929867321666140414104130 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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