Abstract
Owing to the interest that γ-lactams (pyrrolidin-2-ones) deserve for medicinal and natural products chemistry, the development of novel methodologies for synthesis and decoration of the heterocyclic core has become the objective of many synthetic chemists. This review is presented in two parts: whereas Part I highlighted efficient synthetic strategies directed towards lactam ring formation, Part II deals with transformations of γ-lactams (issued between 2001 and 2013) involving introduction of new chains or functional groups or modification of the preexisting ones. Enantioselective synthesis is particularly emphasized, since polysubstituted enantiomerically pure γ- lactams are important for biological testing or can be key intermediates for preparation of bioactive natural products.
Keywords: Enantioselectivity, functionalization, lactams, stereoselectivity, synthetic methods.
Current Organic Chemistry
Title:Recent Advances in Chemistry of γ-Lactams: Part II. Functionalization by C-C or CHeteroatom Bond Formation
Volume: 18 Issue: 12
Author(s): Gianluca Martelli, Antonella Monsignori, Mario Orena and Samuele Rinaldi
Affiliation:
Keywords: Enantioselectivity, functionalization, lactams, stereoselectivity, synthetic methods.
Abstract: Owing to the interest that γ-lactams (pyrrolidin-2-ones) deserve for medicinal and natural products chemistry, the development of novel methodologies for synthesis and decoration of the heterocyclic core has become the objective of many synthetic chemists. This review is presented in two parts: whereas Part I highlighted efficient synthetic strategies directed towards lactam ring formation, Part II deals with transformations of γ-lactams (issued between 2001 and 2013) involving introduction of new chains or functional groups or modification of the preexisting ones. Enantioselective synthesis is particularly emphasized, since polysubstituted enantiomerically pure γ- lactams are important for biological testing or can be key intermediates for preparation of bioactive natural products.
Export Options
About this article
Cite this article as:
Martelli Gianluca, Monsignori Antonella, Orena Mario and Rinaldi Samuele, Recent Advances in Chemistry of γ-Lactams: Part II. Functionalization by C-C or CHeteroatom Bond Formation, Current Organic Chemistry 2014; 18 (12) . https://dx.doi.org/10.2174/1385272819666140407213209
DOI https://dx.doi.org/10.2174/1385272819666140407213209 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
Call for Papers in Thematic Issues
Advances of Heterocyclic Chemistry with Pesticide Activity
Global food safety and security will continue to be a global concern for the next 50 years and beyond. Plant diseases have had a significant impact on food safety and security throughout the entire food chain, from primary production to consumption. While conventional chemical pesticides have been traditionally used for ...read more
Calculation design of covalent/metal organic framework based catalysts
This research area combines theoretical computation and screening with machine learning for the design of covalent/metal organic framework-based catalysts, bridging the disciplines of organic chemistry, physical chemistry, computational chemistry, materials science, and machine learning. It covers several critical aspects: designing and synthesizing organic catalysts for improved performance, applying computational methods ...read more
Carbohydrates conversion in biofuels and bioproducts
Biomass pretreatment, hydrolysis, and saccharification of carbohydrates, and sugars bioconversion in biofuels and bioproducts within a biorefinery framework. Carbohydrates derived from woody biomass, agricultural wastes, algae, sewage sludge, or any other lignocellulosic feedstock are included in this issue. Simulation, techno-economic analysis, and life cycle analysis of a biorefinery process are ...read more
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements