Insights on the Isolation, Biological Activity and Synthetic Protocols of Enyne Derivatives

Title:Insights on the Isolation, Biological Activity and Synthetic Protocols of Enyne Derivatives

Volume: 14 Issue: 8

Author(s): Mohamed El-Shazly, Balaji D. Barve, Michal Korinek, Jing-Ru Liou, Da-Wei Chuang, Yuan-Bin Cheng, Ming-Feng Hou, Jeh-Jeng Wang, Yang-Chang Wu and Fang-Rong Chang

Affiliation:

• School of Pharmacy, College of Pharmacy, China Medical University , Taichung 404, Taiwan.,Taiwan

Keywords: Antiinflammatory, biosynthesis, coupling reactions, cytotoxicity, enynes, sonogashira reaction.

Abstract: Enyne derivatives isolated from terrestrial plants and fungi have recently attracted attention due to their interesting biological activities. It was found that these derivatives possess in general potent antiinflammatory activity which was attributed to the structural similarity of enynes with the natural antiinflammatory agents secreted in the human body. The biosynthesis of some of the isolated enynes has been proposed based on detailed isotope labeling studies. Computational calculations have been utilized to analyze the conformational preferences and forces affecting interaction of some enynes with the target binding sites. Synthesis of enynes has been achieved using several coupling techniques. In the current review we shed some light on the isolation, biological activity, and biosynthetic routes of enynes. We also recount different synthetic methodologies developed for the synthesis of compounds containing enyne functional group.

Cite this article as:

El-Shazly Mohamed, Barve D. Balaji, Korinek Michal, Liou Jing-Ru, Chuang Da-Wei, Cheng Yuan-Bin, Hou Ming-Feng, Wang Jeh-Jeng, Wu Yang-Chang and Chang Fang-Rong, Insights on the Isolation, Biological Activity and Synthetic Protocols of Enyne Derivatives, Current Topics in Medicinal Chemistry 2014; 14(8) . https://dx.doi.org/10.2174/1568026614666140324143523