Generic placeholder image

Protein & Peptide Letters

Editor-in-Chief

ISSN (Print): 0929-8665
ISSN (Online): 1875-5305

In silico Molecular Interaction Analysis of LTNF Peptide-LT10 with Snake Venom Enzymes

Author(s): Sonali G. Chavan and Deepti D. Deobagkar

Volume 21, Issue 7, 2014

Page: [646 - 656] Pages: 11

DOI: 10.2174/0929866521666140320112142

Price: $65

Open Access Journals Promotions 2
Abstract

Lethal Toxin Neutralizing Factor (LTNF) isolated from Opossum (Didephis virginiana) has been shown to exhibit anti-venom and anti-allergic property. The small synthetic peptide- LT10 derived from N-terminal of LTNF also showed this property in vivo. We applied molecular modeling, docking and molecular dynamic (MD) simulation techniques to compute the interaction of LT10 peptide with few snake venom enzymes, namely PLA2 from Naja naja and Atrolysin –C from Crotalus atrox. Our in silico interaction analyses provides molecular basis that might account for antivenom activity of LT10 peptide towards these two snake venom toxins. The understanding of such key molecular interactions could be useful for design and development of better anti-snake venom therapies.

Keywords: Atrolysin C, LT10, LTNF, PLA2, snake envenomation, toxin neutralization.


Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy