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Medicinal Chemistry


ISSN (Print): 1573-4064
ISSN (Online): 1875-6638

Inflammation Markers in Essential Hypertension

Author(s): Dimitrios Tsounis, Georgios Bouras, Georgios Giannopoulos, Charalampos Papadimitriou, Dimitrios Alexopoulos and Spyridon Deftereos

Volume 10, Issue 7, 2014

Page: [672 - 681] Pages: 10

DOI: 10.2174/1573406410666140318111328

Price: $65


Essential hypertension is a common health disorder with uncertain etiology and unclear pathophysiology. There is evidence that various systems interact in uncertain ways and mechanisms to cause hypertension. It is also well known that inflammation is a key feature in the initiation, progression and clinical implication of several cardiovascular diseases. Recently, it has become evident that the immune system and inflammatory response are also essential in the pathogenesis of hypertension.

Many inflammation markers such as CRP, cytokines, and adhesion molecules have been found elevated in hypertensive patients supporting the role of inflammation in the pathogenesis of hypertension. Also, in normotensive individuals, these markers have been associated with the risk of developing hypertension, whereas in hypertensive patients they have been associated with target organ damage as well as with the risk for future cardiovascular events. Thus, understanding the role of inflammation in hypertension provides new insights for novel therapeutic approaches, targeting inflammation for the treatment of hypertension and its complications.

Keywords: Adhesion molecules, biomarkers, CRP, cytokines, hypertension, inflammation, target organ damage, treatment.

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