Abstract
The blood brain barrier, formed by brain capillary endothelial cells, represents the major obstacle for drug entry into the central nervous system. Efforts are ongoing to overcome this barrier without causing permanent damage to brain tissue. The present review attempts to provide key information on cerebral microvessel anatomy, features contributing to barrier function and current approaches in overcoming the blood-brain barrier using cellular and molecular methodologies to transfer drugs to the brain as well as intelligent drug delivery systems.
Keywords: blood-brain barrier, p-glycoprotein, drug delivery systems, nanoparticles, Immuno-liposomes
Current Nanoscience
Title: Drug Delivery Across the Blood-Brain Barrier
Volume: 1 Issue: 3
Author(s): Anika M.S. Hartz, Bjorn Bauer, Carsten H. Baehr, David S. Miller and Gert Fricker
Affiliation:
Keywords: blood-brain barrier, p-glycoprotein, drug delivery systems, nanoparticles, Immuno-liposomes
Abstract: The blood brain barrier, formed by brain capillary endothelial cells, represents the major obstacle for drug entry into the central nervous system. Efforts are ongoing to overcome this barrier without causing permanent damage to brain tissue. The present review attempts to provide key information on cerebral microvessel anatomy, features contributing to barrier function and current approaches in overcoming the blood-brain barrier using cellular and molecular methodologies to transfer drugs to the brain as well as intelligent drug delivery systems.
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Cite this article as:
Hartz M.S. Anika, Bauer Bjorn, Baehr H. Carsten, Miller S. David and Fricker Gert, Drug Delivery Across the Blood-Brain Barrier, Current Nanoscience 2005; 1 (3) . https://dx.doi.org/10.2174/157341305774642948
DOI https://dx.doi.org/10.2174/157341305774642948 |
Print ISSN 1573-4137 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6786 |
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