Abstract
Lyme borreliosis (LB), caused by Borrelia burgdorferi (B.b.), is the most frequently diagnosed tick-borne zoonosis in temperate zones of the Northern hemisphere. Borrelia is unique among bacteria in its ability to express a wide variety of lipoproteins on its surface, which play an essential role in pathogenesis. Surface proteins of spirochetes are important virulence determinants, immune evasion molecules and adaptation factors in the transmission and interaction with host tissues. Vast diversity in the expressed surface proteome of Borrelia in different niches and multifunctionality of proteins are the major strategies of Borrelia to avoid the destructive effect of immune system. In this review we provide deep insight into the protein:protein interactions that take place between different stages of life of Borrelia. Precise knowledge of surface proteins may help in improvement of the vaccines as well as for therapeutic agents against borreliosis.
Keywords: Borrelia, immune evasion, lyme disease, protein, protein interactions, surface proteins, ticks.
Current Protein & Peptide Science
Title:Outer Surface Proteins of Borrelia: Peerless Immune Evasion Tools
Volume: 15 Issue: 1
Author(s): Lucia Pulzova and Mangesh Bhide
Affiliation:
Keywords: Borrelia, immune evasion, lyme disease, protein, protein interactions, surface proteins, ticks.
Abstract: Lyme borreliosis (LB), caused by Borrelia burgdorferi (B.b.), is the most frequently diagnosed tick-borne zoonosis in temperate zones of the Northern hemisphere. Borrelia is unique among bacteria in its ability to express a wide variety of lipoproteins on its surface, which play an essential role in pathogenesis. Surface proteins of spirochetes are important virulence determinants, immune evasion molecules and adaptation factors in the transmission and interaction with host tissues. Vast diversity in the expressed surface proteome of Borrelia in different niches and multifunctionality of proteins are the major strategies of Borrelia to avoid the destructive effect of immune system. In this review we provide deep insight into the protein:protein interactions that take place between different stages of life of Borrelia. Precise knowledge of surface proteins may help in improvement of the vaccines as well as for therapeutic agents against borreliosis.
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Cite this article as:
Pulzova Lucia and Bhide Mangesh, Outer Surface Proteins of Borrelia: Peerless Immune Evasion Tools, Current Protein & Peptide Science 2014; 15 (1) . https://dx.doi.org/10.2174/1389203715666140221124213
DOI https://dx.doi.org/10.2174/1389203715666140221124213 |
Print ISSN 1389-2037 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5550 |
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