[6]-gingerol as a Cancer Chemopreventive Agent: A Review of Its Activity on Different Steps of the Metastatic Process

Title:[6]-gingerol as a Cancer Chemopreventive Agent: A Review of Its Activity on Different Steps of the Metastatic Process

Volume: 14 Issue: 4

Author(s): Juliana Poltronieri, Amanda B. Becceneri, Angelina M. Fuzer, Julio Cesar C. Filho, Ana Carolina B.M. Martin, Paulo Cezar Vieira, Normand Pouliot and Márcia R. Cominetti

Affiliation:

Keywords: Apoptosis, cancer, ginger, 6-gingerol, metastasis, natural product.

Abstract: For many years, ginger or ginger root, the rhizome of the plant Zingiber officinale, has been consumed as a delicacy, medicine, or spice. Several studies have been conducted on the medicinal properties of ginger against various disorders, including cancer. Cancer is the second leading cause of death, and chemoprevention is defined as the use of natural or synthetic substances to prevent cancer initiation or progression. Evidence that ginger-derived compounds have inhibitory effects on various cancer cell types is increasingly being reported in the scientific literature. In this review we focused on the cancer chemopreventive effects of [6]-gingerol, the major pungent component of ginger, and its impact on different steps of the metastatic process.

Cite this article as:

Poltronieri Juliana, Becceneri B. Amanda, Fuzer M. Angelina, Filho Cesar C. Julio, Martin Carolina B.M. Ana, Vieira Cezar Paulo, Pouliot Normand and Cominetti R. Márcia, [6]-gingerol as a Cancer Chemopreventive Agent: A Review of Its Activity on Different Steps of the Metastatic Process, Mini-Reviews in Medicinal Chemistry 2014; 14 (4) . https://dx.doi.org/10.2174/1389557514666140219095510