Emerging Roles of microRNAs in Neural Stem Cells

Title:Emerging Roles of microRNAs in Neural Stem Cells

Volume: 9 Issue: 3

Author(s): Sheng Wang, Juan Xu, Rui Ye, Jing Wang, Zhaozhao Chen, Renhuan Huang, Qiang Peng, Yuanzhi Xu and Xiaoxiao Cai

Affiliation:

• Department of Stomatology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, No. 301, Middle Yanchang Road, Shanghai 200072, P.R. China.,China

Keywords: Adult neural stem cell, differentiation, embryonic neural stem cell, microRNAs, proliferation, regulation

Abstract: Neural stem cells (NSCs) are a small subset of primitive precursors that generate and maintain the main phenotypes of the nervous system. Their ability to undergo long-term proliferation and neural differentiation endows them with great potential in regenerative medicine. Therefore, the mechanisms by which NSCs are regulated have been widely explored to improve their therapeutic efficacy in treating neurologic disorders. Recent progress has highlighted the significance of microRNAs (miRNAs) in the regulation of NSC behavior. Thus, to sketch out a comprehensive image of the regulatory mechanisms of miRNAs in NSCs, we here summarize existing evidence of the regulatory roles of diversified miRNAs in the proliferation and neural differentiation of NSCs during embryonic neurodevelopment and adult brain maintenance.

Cite this article as:

Wang Sheng, Xu Juan, Ye Rui, Wang Jing, Chen Zhaozhao, Huang Renhuan, Peng Qiang, Xu Yuanzhi and Cai Xiaoxiao, Emerging Roles of microRNAs in Neural Stem Cells, Current Stem Cell Research & Therapy 2014; 9(3) . https://dx.doi.org/10.2174/1574888X09666140213201846