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Letters in Organic Chemistry


ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

Catalyst Free One-pot Three-component Synthesis of 2-Amino-4Hchromene Derivatives in Aqueous Deep Eutectic Mixture at Room Temperature

Author(s): Atul Chaskar

Volume 11, Issue 7, 2014

Page: [480 - 486] Pages: 7

DOI: 10.2174/1570178611666140210213413

Price: $65


Multifunctional chromenes have been efficiently synthesized in aqueous medium at room temperature using deep eutectic mixture of choline chloride:urea. In this one-pot synthesis, the benzylidenemalononitrile firstly formed by Knoevenagel condensation of aldehyde and malononitrile eventually underwent Michael addition-cyclization with dimedone and offered the chromenes in good to excellent yield.

Keywords: 5-exo-Cyclisation, 6-endo Cyclization, AIBN, Pyrimidine, Radical reaction, Sulfur heterocycles, Tributyltin hydride.

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