Synthesis and Biological Activity of New Fluorinated Thieno[2,3-d]pyrimidinyl Hydrazone Derivatives

Title:Synthesis and Biological Activity of New Fluorinated Thieno[2,3-d]pyrimidinyl Hydrazone Derivatives

Volume: 11 Issue: 5

Author(s): Xin-Jian Song, Ping Yang, Dai-Fu Wang and Zhi-Dou Tan

Affiliation:

Keywords: Crystal structure, fungicidal activity, hydrazones, thieno[2, 3-d]pyrimidines, trifluoromethyl group.

Abstract: A series of new fluorinated thieno[2,3-d]pyrimidine derivatives containing hydrazone substructure was synthesized by a five-step procedure, including trifluoroacetylation, cyclization, chlorination, substitution by hydrazine, and condensation reaction. The structures of these newly synthesized compounds were confirmed by IR, NMR, EI-MS, elemental analysis and single-crystal X-ray diffraction. The preliminary bioassay result showed that some title compounds exhibited relatively good fungicidal activity against Fusarium oxysporium f.sp.vasinfectum at the concentration of 50 μgmL^-1, especially the inhibition rate of compound 6b reached above 90%.

Cite this article as:

Song Xin-Jian, Yang Ping, Wang Dai-Fu and Tan Zhi-Dou, Synthesis and Biological Activity of New Fluorinated Thieno[2,3-d]pyrimidinyl Hydrazone Derivatives, Letters in Organic Chemistry 2014; 11 (5) . https://dx.doi.org/10.2174/1570178611666140207220959