Almost 200 species fungus are associated with human infections have been described. The musculoskeletal involvement can develop by direct extension of a lesion or by inoculation and hematogenous spread. The joint infection has an indolent course and diagnosis tends to be delayed because of the paucity of clinical signs and the rarity of the pathology. Despite the small number of fungal species involved, the incidence of diseases they can provoke has increased over the last 40 years particularly in hospital environments which has resulted in individuals having their immunologic system compromised. There is no special prevalence for gender or age. A review of the joint involvement in such conditions is described on this chapter.