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Letters in Organic Chemistry


ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

An Alternative Stereoselective Total Synthesis of (+)-Cephalosporolide D

Author(s): Indraganti Sreenivasa Murthy, Reddymasu Sreenivasulu, Gurrala Alluraiah and Rudraraju Ramesh Raju

Volume 11, Issue 5, 2014

Page: [327 - 332] Pages: 6

DOI: 10.2174/1570178611666140124001937

Price: $65


An efficient stereoselective total synthesis of (+)-Cephalosporolide D from commercially available and inexpensive starting material, (±)-propylene epoxide, is described. The key steps involved in this synthesis are α- aminoxylation catalyzed by L-proline, followed by in situ reduction using NaBH4 and Yamaguchi macrolactonization.

Keywords: (+)-Cephalosporolide D, L - Proline catalyzed reaction, (±)-Propylene epoxide, stereoselective synthesis, total synthesis and Yamaguchi macrolactonization.

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