An Alternative Stereoselective Total Synthesis of (+)-Cephalosporolide D

Title:An Alternative Stereoselective Total Synthesis of (+)-Cephalosporolide D

Volume: 11 Issue: 5

Author(s): Indraganti Sreenivasa Murthy, Reddymasu Sreenivasulu, Gurrala Alluraiah and Rudraraju Ramesh Raju

Affiliation:

Keywords: (+)-Cephalosporolide D, L - Proline catalyzed reaction, (±)-Propylene epoxide, stereoselective synthesis, total synthesis and Yamaguchi macrolactonization.

Abstract: An efficient stereoselective total synthesis of (+)-Cephalosporolide D from commercially available and inexpensive starting material, (±)-propylene epoxide, is described. The key steps involved in this synthesis are α- aminoxylation catalyzed by L-proline, followed by in situ reduction using NaBH₄ and Yamaguchi macrolactonization.

Cite this article as:

Murthy Sreenivasa Indraganti, Sreenivasulu Reddymasu, Alluraiah Gurrala and Raju Ramesh Rudraraju, An Alternative Stereoselective Total Synthesis of (+)-Cephalosporolide D, Letters in Organic Chemistry 2014; 11(5) . https://dx.doi.org/10.2174/1570178611666140124001937